COVID-19 (SARS-CoV-2) infection and thrombotic conditions: A systematic review and meta-analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorGabbai-Armelin, Paulo Roberto [UNESP]-
Autor(es): dc.creatorde Oliveira, Analú Barros [UNESP]-
Autor(es): dc.creatorFerrisse, Túlio Morandin [UNESP]-
Autor(es): dc.creatorSales, Luciana Solera [UNESP]-
Autor(es): dc.creatorBarbosa, Elis Rodrigues Oliveira [UNESP]-
Autor(es): dc.creatorMiranda, Marina Lins [UNESP]-
Autor(es): dc.creatorSalomão, Karina Borges [UNESP]-
Autor(es): dc.creatorBrighenti, Fernanda Lourenção [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:46:28Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:28Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/eci.13559-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206207-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206207-
Descrição: dc.descriptionBackground: COVID-19 is an infectious disease caused by SARS-CoV-2 associated with haematological manifestations (thrombolytic events). Aims: Considering the high prevalence of the thrombotic scenarios associated with COVID-19, the aim of this study was to perform a systematic review of the available literature, concerning the relation of COVID-19 and the thrombotic events, and identify prognostic factors for these events. Materials & Methods: PubMed, Web of Science and Scopus databases were searched. Independent reviewers conducted all flow diagram steps. For qualitative analysis, Oxford level of evidence and Newcastle-Ottawa scale were used in the eligible articles. For the prognostic factors, a meta-analysis was conducted to age, number of neutrophils and platelets, and levels of ferritin, C-reactive protein, lactate dehydrogenase and D-dimer. Publication bias was accessed by funnel plot and by trim-and-fill test. Trim-and-fill test was also applied to evaluate meta-analysis bias. Results: Twenty articles were included in the qualitative analysis, and 6 articles were included in the meta-analysis. Case-control studies showed bias related to exposure, and the main bias in cohort studies were related to selection and outcome. All articles received score 4 for the level of evidence. Hypertension and diabetes were the comorbidities more frequently associated with thrombolytic events. Significant results were found regarding D-dimer (P <.0001) and age (P =.0202) for thrombotic events in patients diagnosed with COVID-19. Conclusion: Patients older than 60 years, with hypertension, diabetes and D-Dimer values above 3.17 µg/mL, can be considered prognostic factors for developing thrombotic events due to COVID-19.-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationEuropean Journal of Clinical Investigation-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectD-dimer-
Palavras-chave: dc.subjectmeta-analysis-
Palavras-chave: dc.subjectprognostic factors-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectsystematic review-
Palavras-chave: dc.subjectthrombosis-
Título: dc.titleCOVID-19 (SARS-CoV-2) infection and thrombotic conditions: A systematic review and meta-analysis-
Aparece nas coleções:Repositório Institucional - Unesp

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