Characterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Oxford-
Autor(es): dc.contributorHospital Israelita Albert Einstein-
Autor(es): dc.creatorBarbosa, Maurício Fregonesi [UNESP]-
Autor(es): dc.creatorFusco, Daniéliso Renato [UNESP]-
Autor(es): dc.creatorGaiolla, Rafael Dezen [UNESP]-
Autor(es): dc.creatorWerys, Konrad-
Autor(es): dc.creatorTanni, Suzana Erico [UNESP]-
Autor(es): dc.creatorFernandes, Rômulo Araújo [UNESP]-
Autor(es): dc.creatorRibeiro, Sergio Marrone [UNESP]-
Autor(es): dc.creatorSzarf, Gilberto-
Data de aceite: dc.date.accessioned2022-02-22T00:46:25Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:25Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12872-021-01996-6-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206193-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206193-
Descrição: dc.descriptionBackground: The use of anthracycline-based chemotherapy is associated with the development of heart failure, even years after the end of treatment. Early detection of cardiac dysfunction could identify a high-risk subset of survivors who would eventually benefit from early intervention. Cardiac magnetic resonance feature-tracking (CMR-FT) analysis offers a practical and rapid method to calculate systolic and diastolic strains from routinely acquired cine images. While early changes in systolic function have been described, less data are available about late effects of chemotherapy in diastolic parameters by CMR-FT. The main goal of this study was to determine whether left ventricular (LV) early diastolic strain rates (GDSR-E) by CMR-FT are impaired in long-term adult survivors of non-Hodgkin lymphoma (NHL). Our secondary objective was to analyze associations between GDSR-E with cumulative anthracycline dose, systolic function parameters and myocardial tissue characteristics. Methods: This is a single center cross-sectional observational study of asymptomatic patients in remission of NHL who previously received anthracycline therapy. All participants underwent their CMR examination on a 3.0-T scanner, including cines, T2 mapping, T1 mapping and late gadolinium enhancement imaging. Derived myocardial extracellular volume fraction was obtained from pre- and post-contrast T1 maps. CMR-FT analysis was performed using Trufi Strain software. The data obtained were compared between anthracycline group and volunteers without cardiovascular disease or neoplasia. Results: A total of 18 adult survivors of NHL, 14 (77.8%) males, at mean age of 57.6 (± 14.7) years-old, were studied 88.2 (± 52.1) months after exposure to anthracycline therapy (median 400 mg/m2). Compared with controls, anthracycline group showed impaired LV global early diastolic circumferential strain rate (GCSR-E) [53.5%/s ± 19.3 vs 72.2%/s ± 26.7, p = 0.022], early diastolic longitudinal strain rate (GLSR-E) [40.4%/s ± 13.0 vs 55.9%/s ± 17.8, p = 0.006] and early diastolic radial strain rate (GRSR-E) [− 114.4%/s ± 37.1 vs − 170.5%/s ± 48.0, p < 0.001]. Impaired LV GCSR-E, GLSR-E and GRSR-E correlated with increased anthracycline dose and decreased systolic function. There were no correlations between GDSR-E and myocardial tissue characteristics. Conclusions: Left ventricular early diastolic strain rates by CMR-FT are impaired late after anthracycline chemotherapy in adult survivors of non-Hodgkin lymphoma.-
Descrição: dc.descriptionDepartment of Diagnostic Imaging Universidade Federal de São Paulo (UNIFESP), Rua Napoleão de Barros 800, Vila Clementino-
Descrição: dc.descriptionDepartment of Tropical Diseases and Diagnostic Imaging Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionCardiology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionHematology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionUniversity of Oxford Centre for Clinical Magnetic Resonance Research (OCMR) University of Oxford-
Descrição: dc.descriptionPneumology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionHospital Israelita Albert Einstein-
Descrição: dc.descriptionDepartment of Tropical Diseases and Diagnostic Imaging Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionCardiology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionHematology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionPneumology Division Internal Medicine Department Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education Universidade Estadual Paulista (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationBMC Cardiovascular Disorders-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCancer-
Palavras-chave: dc.subjectChemotherapy-
Palavras-chave: dc.subjectDiastolic dysfunction-
Palavras-chave: dc.subjectFeature-tracking-
Palavras-chave: dc.subjectStrain-
Título: dc.titleCharacterization of subclinical diastolic dysfunction by cardiac magnetic resonance feature-tracking in adult survivors of non-Hodgkin lymphoma treated with anthracyclines-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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