A comparative in silico analysis of cd24’s prognostic value in human and canine prostate cancer

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorThe University of Queensland-UQ-
Autor(es): dc.contributorFaculdade de Ensino Superior e Formação Integral-FAEF-
Autor(es): dc.contributorPaulista University–UNIP-
Autor(es): dc.creatorLeis-Filho, Antonio Fernando [UNESP]-
Autor(es): dc.creatorLainetti, Patrícia de Faria [UNESP]-
Autor(es): dc.creatorFranzoni, Mayara Simão [UNESP]-
Autor(es): dc.creatorPalmieri, Chiara-
Autor(es): dc.creatorKobayshi, Priscila Emiko [UNESP]-
Autor(es): dc.creatorLaufer-Amorim, Renee [UNESP]-
Autor(es): dc.creatorFonseca-Alves, Carlos Eduardo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:46:20Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:20Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jpm11030232-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206166-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206166-
Descrição: dc.descriptionCD24 is a cell surface molecule anchored by glycosyl-phosphatidyl-inositol and expressed by different human cancers, including prostate cancer (PC). Some studies have demonstrated that CD24 expression is associated with poor patient outcome; however, few studies have investigated CD24 expression in spontaneous animal models of human PC, such as canine PC. This study aimed to evaluate the expression of CD24 in human PC using the in silico analysis of the data obtained from The Cancer Genome Atlas (TCGA) and comparing it with the previously published prostatic canine transcriptome data. In addition, CD24 expression was confirmed by immunohistochemistry in an independent cohort of canine prostatic samples and its prognostic significance assessed. The systematic review identified 10 publications fitting with the inclusion criteria of this study. Of the 10 manuscripts, 5 demonstrated a direct correlation between CD24 overexpression and patient prognoses. CD24 expression was also associated with PSA relapse (2/5) and tumor progression (1/5). However, the in silico analysis did not validate CD24 as a prognostic factor of human PC. Regarding canine PC, 10 out of 30 normal prostates and 27 out of 40 PC samples were positive for CD24. As in humans, there was no association with overall survival. Overall, our results demonstrated a significant CD24 overexpression in human and canine prostate cancer, although its prognostic value may be questionable. However, tumors overexpressing CD24 may be a reliable model for new target therapies and dogs could be used of a unique preclinical model for these studies.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction Sao Paulo State University-UNESP-
Descrição: dc.descriptionSchool of Veterinary Science Gatton Campus The University of Queensland-UQ-
Descrição: dc.descriptionDepartment of Veterinary Clinic Sao Paulo State University-UNESP-
Descrição: dc.descriptionLaboratório de Patologia Faculdade de Ensino Superior e Formação Integral-FAEF-
Descrição: dc.descriptionInstitute of Health Sciences Paulista University–UNIP-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Reproduction Sao Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Veterinary Clinic Sao Paulo State University-UNESP-
Descrição: dc.descriptionFAPESP: 2019/00765-3-
Descrição: dc.descriptionFAPESP: 2021/02702-9-
Descrição: dc.descriptionCNPq: 422139/2018-1-
Idioma: dc.languageen-
Relação: dc.relationJournal of Personalized Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCarcinoma-
Palavras-chave: dc.subjectCD24-
Palavras-chave: dc.subjectComparative oncology-
Palavras-chave: dc.subjectDog-
Palavras-chave: dc.subjectProstate-
Título: dc.titleA comparative in silico analysis of cd24’s prognostic value in human and canine prostate cancer-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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