In vivo biocompatibility and biodegradability of poly(lactic acid)/poly(ϵ-caprolactone) blend compatibilized with poly(ϵ-caprolactone-b-tetrahydrofuran) in Wistar rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorConde, Gabriel [UNESP]-
Autor(es): dc.creatorDe Carvalho, Júlia Ribeiro Garcia [UNESP]-
Autor(es): dc.creatorDias, Paula Do Patrocínio-
Autor(es): dc.creatorMoranza, Henriette Gellert [UNESP]-
Autor(es): dc.creatorMontanhim, Gabriel Luiz [UNESP]-
Autor(es): dc.creatorRibeiro, Juliana De Oliveira [UNESP]-
Autor(es): dc.creatorChinelatto, Marcelo Aparecido-
Autor(es): dc.creatorMoraes, Paola Castro [UNESP]-
Autor(es): dc.creatorTaboga, Sebasti o Roberto [UNESP]-
Autor(es): dc.creatorBertolo, Paulo Henrique Leal [UNESP]-
Autor(es): dc.creatorGon alves Funnicelli, Michelli Inácio [UNESP]-
Autor(es): dc.creatorPinheiro, Daniel Guariz [UNESP]-
Autor(es): dc.creatorFerraz, Guilherme De Camargo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:46:19Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:19Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1088/2057-1976/abeb5a-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206160-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206160-
Descrição: dc.descriptionPoly(lactic acid) (PLA) and poly(ϵ-caprolactone) (PCL) are two important aliphatic esters known for their biodegradability and bioresorbability properties; the former is stiffer and brittle while the smaller modulus of the latter allows a suitable elongation. The new biomaterials being developed from the blend of these two polymers (PLA and PCL) is opportune due to the reducing interfacial tension between their immiscible phases. In a previous study, PLA/PCL immiscible blend when compatibilized with poly(ϵ-caprolactone-b-tetrahydrofuran) resulted in enhanced ductility and toughness no cytotoxic effect in vitro tests. There is little published data on the effect of poly(ϵ-caprolactone-b-tetrahydrofuran) on PLA and PCL biocompatibility and biodegradability in vivo tests. This study focuses on evaluating the behavioral response and polymer-tissue interaction of compatibilized PLA/PCL blend compared to neat PLA implanted via intraperitoneal (IP) and subcutaneous (SC) in male Wistar rats, distributed in four experimental groups: neat PLA, PLA/PCL blend, sham, and control at 2-, 8- and 24-weeks post-implantation (WPI). An open-field test was performed to appraise emotionality and spontaneous locomotor activity. Histopathological investigation using hematoxylin-eosin (H&E) and picrosirius-hematoxylin (PSH) was used to assess polymer-tissue interaction. Modifications in PLA and the PLA/PCL blend's surface morphology were determined by scanning electron microscopy (SEM). PLA group defecated more often than PLA/PCL rats 2 and 8 WPI. Conjunctive capsule development around implants, cell adhesion, angiogenesis, and giant cells of a foreign body to the biomaterial was observed in light microscopy. Both groups displayed a fibrous reaction along with collagen deposition around the biomaterials. In the SEM, the images showed a higher degradation rate for the PLA/PCL blend in both implantation routes. The polymers implanted via IP exhibited a higher degradation rate compared to SC. These findings emphasize the biocompatibility of the PLA/PCL blend compatibilized with poly(ϵ-caprolactone-b-tetrahydrofuran), making this biopolymer an acceptable alternative in a variety of biomedical applications.-
Descrição: dc.descriptionLaboratory of Equine Exercise Physiology and Pharmacology (LAFEQ) Department of Animal Morphology and Physiology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Clinic and Surgery School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Materials Engineering São Carlos School of Engineering University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Biology UNESP - São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Veterinary Pathology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Technology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)-
Descrição: dc.descriptionLaboratory of Equine Exercise Physiology and Pharmacology (LAFEQ) Department of Animal Morphology and Physiology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Clinic and Surgery School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Biology UNESP - São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Veterinary Pathology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Technology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp)-
Idioma: dc.languageen-
Relação: dc.relationBiomedical Physics and Engineering Express-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiodegradable-
Palavras-chave: dc.subjectbiodegradation-
Palavras-chave: dc.subjectcompatibilization-
Palavras-chave: dc.subjectheatmap-
Palavras-chave: dc.subjectopen-field-
Palavras-chave: dc.subjectPCL-
Título: dc.titleIn vivo biocompatibility and biodegradability of poly(lactic acid)/poly(ϵ-caprolactone) blend compatibilized with poly(ϵ-caprolactone-b-tetrahydrofuran) in Wistar rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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