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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.creator | Conde, Gabriel [UNESP] | - |
Autor(es): dc.creator | De Carvalho, Júlia Ribeiro Garcia [UNESP] | - |
Autor(es): dc.creator | Dias, Paula Do Patrocínio | - |
Autor(es): dc.creator | Moranza, Henriette Gellert [UNESP] | - |
Autor(es): dc.creator | Montanhim, Gabriel Luiz [UNESP] | - |
Autor(es): dc.creator | Ribeiro, Juliana De Oliveira [UNESP] | - |
Autor(es): dc.creator | Chinelatto, Marcelo Aparecido | - |
Autor(es): dc.creator | Moraes, Paola Castro [UNESP] | - |
Autor(es): dc.creator | Taboga, Sebasti o Roberto [UNESP] | - |
Autor(es): dc.creator | Bertolo, Paulo Henrique Leal [UNESP] | - |
Autor(es): dc.creator | Gon alves Funnicelli, Michelli Inácio [UNESP] | - |
Autor(es): dc.creator | Pinheiro, Daniel Guariz [UNESP] | - |
Autor(es): dc.creator | Ferraz, Guilherme De Camargo [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:46:19Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:46:19Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-05-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1088/2057-1976/abeb5a | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/206160 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/206160 | - |
Descrição: dc.description | Poly(lactic acid) (PLA) and poly(ϵ-caprolactone) (PCL) are two important aliphatic esters known for their biodegradability and bioresorbability properties; the former is stiffer and brittle while the smaller modulus of the latter allows a suitable elongation. The new biomaterials being developed from the blend of these two polymers (PLA and PCL) is opportune due to the reducing interfacial tension between their immiscible phases. In a previous study, PLA/PCL immiscible blend when compatibilized with poly(ϵ-caprolactone-b-tetrahydrofuran) resulted in enhanced ductility and toughness no cytotoxic effect in vitro tests. There is little published data on the effect of poly(ϵ-caprolactone-b-tetrahydrofuran) on PLA and PCL biocompatibility and biodegradability in vivo tests. This study focuses on evaluating the behavioral response and polymer-tissue interaction of compatibilized PLA/PCL blend compared to neat PLA implanted via intraperitoneal (IP) and subcutaneous (SC) in male Wistar rats, distributed in four experimental groups: neat PLA, PLA/PCL blend, sham, and control at 2-, 8- and 24-weeks post-implantation (WPI). An open-field test was performed to appraise emotionality and spontaneous locomotor activity. Histopathological investigation using hematoxylin-eosin (H&E) and picrosirius-hematoxylin (PSH) was used to assess polymer-tissue interaction. Modifications in PLA and the PLA/PCL blend's surface morphology were determined by scanning electron microscopy (SEM). PLA group defecated more often than PLA/PCL rats 2 and 8 WPI. Conjunctive capsule development around implants, cell adhesion, angiogenesis, and giant cells of a foreign body to the biomaterial was observed in light microscopy. Both groups displayed a fibrous reaction along with collagen deposition around the biomaterials. In the SEM, the images showed a higher degradation rate for the PLA/PCL blend in both implantation routes. The polymers implanted via IP exhibited a higher degradation rate compared to SC. These findings emphasize the biocompatibility of the PLA/PCL blend compatibilized with poly(ϵ-caprolactone-b-tetrahydrofuran), making this biopolymer an acceptable alternative in a variety of biomedical applications. | - |
Descrição: dc.description | Laboratory of Equine Exercise Physiology and Pharmacology (LAFEQ) Department of Animal Morphology and Physiology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp) | - |
Descrição: dc.description | Department of Clinic and Surgery School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp) | - |
Descrição: dc.description | Department of Materials Engineering São Carlos School of Engineering University of São Paulo (USP) | - |
Descrição: dc.description | Department of Biology UNESP - São Paulo State University (Unesp) | - |
Descrição: dc.description | Department of Veterinary Pathology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp) | - |
Descrição: dc.description | Department of Technology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp) | - |
Descrição: dc.description | Laboratory of Equine Exercise Physiology and Pharmacology (LAFEQ) Department of Animal Morphology and Physiology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp) | - |
Descrição: dc.description | Department of Clinic and Surgery School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp) | - |
Descrição: dc.description | Department of Biology UNESP - São Paulo State University (Unesp) | - |
Descrição: dc.description | Department of Veterinary Pathology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp) | - |
Descrição: dc.description | Department of Technology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Biomedical Physics and Engineering Express | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | biodegradable | - |
Palavras-chave: dc.subject | biodegradation | - |
Palavras-chave: dc.subject | compatibilization | - |
Palavras-chave: dc.subject | heatmap | - |
Palavras-chave: dc.subject | open-field | - |
Palavras-chave: dc.subject | PCL | - |
Título: dc.title | In vivo biocompatibility and biodegradability of poly(lactic acid)/poly(ϵ-caprolactone) blend compatibilized with poly(ϵ-caprolactone-b-tetrahydrofuran) in Wistar rats | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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