Nerve Growth Factor–Induced Sensitization of the Sternocleidomastoid Muscle and Its Effects on Trigeminal Muscle Sensitivity and Pain Profiles: A Randomized Double-Blind Controlled Study

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorAarhus University-
Autor(es): dc.contributorScandinavian Center for Orofacial Neurosciences (SCON)-
Autor(es): dc.contributorKarolinska Institutet Huddinge-
Autor(es): dc.creatorde Caxias, Fernanda Pereira [UNESP]-
Autor(es): dc.creatorExposto, Fernando Gustavo-
Autor(es): dc.creatorTurcio, Karina Helga Leal [UNESP]-
Autor(es): dc.creatordos Santos, Daniela Micheline [UNESP]-
Autor(es): dc.creatorSvensson, Peter-
Data de aceite: dc.date.accessioned2022-02-22T00:46:11Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:11Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.11607/ofph.2593-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206105-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206105-
Descrição: dc.descriptionAims: To investigate whether localized sensitization of the sternocleidomastoid (SCM) muscle using nerve growth factor (NGF) would affect masseter and anterior temporalis muscle sensitivity and pain profiles. Methods: A total of 28 healthy participants attended two sessions (T0 and T1). At T0, the maximum voluntary occlusal bite force (MVOBF), as well as pressure pain thresholds (PPT), mechanical sensitivity, and referred pain/sensations for the SCM, masseter, and temporalis muscles, were assessed. Participants also completed the Pain Catastrophizing Scale (PCS), the Pain Vigilance and Awareness Questionnaire (PVAQ), and the Neck Disability Index (NDI). After these assessments, 14 participants received an injection of NGF into the SCM, and 14 received an injection of isotonic saline solution. At T (48 hours postinjection), the participants were again submitted to the same evaluations. Results: NGF caused significant mechanical sensitization in the SCM (P <.025), but not in the masseter or temporalis muscles (P >.208). It also caused significant increases in NDI score (P =.004). No statistically significant differences were found for MVOBF, frequency of referred pain/sensations, or questionnaire scores (P >.248). Conclusion: These results suggest that 48 hours after localized sensitization of the SCM, the primary response is impairment of neck function, but not jaw function. J Oral Facial Pain Headache 2021;35:7–16. doi: 10.11607/ofph.2593-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSection of Orofacial Pain and Jaw Function Department of Dentistry Faculty of Health Aarhus University-
Descrição: dc.descriptionScandinavian Center for Orofacial Neurosciences (SCON)-
Descrição: dc.descriptionDepartment of Dental Medicine Karolinska Institutet Huddinge-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2018/00770-4-
Formato: dc.format7-16-
Idioma: dc.languageen-
Relação: dc.relationJournal of Oral and Facial Pain and Headache-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbehavior-
Palavras-chave: dc.subjectmasticatory muscles-
Palavras-chave: dc.subjectmusculoskeletal pain-
Palavras-chave: dc.subjectneck pain-
Palavras-chave: dc.subjectnerve growth factor-
Título: dc.titleNerve Growth Factor–Induced Sensitization of the Sternocleidomastoid Muscle and Its Effects on Trigeminal Muscle Sensitivity and Pain Profiles: A Randomized Double-Blind Controlled Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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