Cystic proliferation of germline stem cells is necessary to reproductive success and normal mating behavior in Medaka

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorINTECH (CONICET-UNSAM)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorSao Paulo Fisheries Institute (APTA/SAA)-
Autor(es): dc.creatorPadilla, Luisa F Arias-
Autor(es): dc.creatorCastañeda-Cortés, Diana C. [UNESP]-
Autor(es): dc.creatorRosa, Ivana F. [UNESP]-
Autor(es): dc.creatorAcosta, Omar D Moreno-
Autor(es): dc.creatorHattori, Ricardo S. [UNESP]-
Autor(es): dc.creatorNóbrega, Rafael H.-
Autor(es): dc.creatorFernandino, Juan I.-
Data de aceite: dc.date.accessioned2022-02-22T00:46:07Z-
Data de disponibilização: dc.date.available2022-02-22T00:46:07Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.7554/eLife.62757-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206081-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206081-
Descrição: dc.descriptionThe production of an adequate number of gametes is necessary for normal reproduction, for which the regulation of proliferation from early gonadal development to adulthood is key in both sexes. Cystic proliferation of germline stem cells is an especially important step prior to the beginning of meiosis; however, the molecular regulators of this proliferation remain elusive in vertebrates. Here, we report that ndrg1b is an important regulator of cystic proliferation in medaka. We generated mutants of ndrg1b that led to a disruption of cystic proliferation of germ cells. This loss of cystic proliferation was observed from embryogenic to adult stages, impacting the success of gamete production and reproductive parameters such as spawning and fertilization. Interestingly, the depletion of cystic proliferation also impacted male sexual behavior, with a decrease of mating vigor. These data illustrate why it is also necessary to consider gamete production capacity in order to analyze reproductive behavior.-
Descrição: dc.descriptionConsejo Nacional de Investigaciones Científicas y Técnicas-
Descrição: dc.descriptionAgencia Nacional de Promoción Científica y Tecnológica-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstituto Tecnológico de Chascomús INTECH (CONICET-UNSAM)-
Descrição: dc.descriptionReproductive and Molecular Biology Group Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSalmonid Experimental Station at Campos do Jordão UPD-CJ Sao Paulo Fisheries Institute (APTA/SAA)-
Descrição: dc.descriptionReproductive and Molecular Biology Group Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionAgencia Nacional de Promoción Científica y Tecnológica: 0366/12-
Descrição: dc.descriptionFAPESP: 14/07620-7-
Descrição: dc.descriptionFAPESP: 18/10265-5-
Descrição: dc.descriptionAgencia Nacional de Promoción Científica y Tecnológica: 2501/15-
Descrição: dc.descriptionFAPESP: D 2979/16-
Idioma: dc.languageen-
Relação: dc.relationeLife-
???dc.source???: dc.sourceScopus-
Título: dc.titleCystic proliferation of germline stem cells is necessary to reproductive success and normal mating behavior in Medaka-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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