Taurine Chloramine and Hydrogen Peroxide as a Potential Source of Singlet Oxygen for Topical Application

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorXimenes, Valdecir F. [UNESP]-
Autor(es): dc.creatorXimenes, Thomaz P. [UNESP]-
Autor(es): dc.creatorMorgon, Nelson H.-
Autor(es): dc.creatorde Souza, Aguinaldo R. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:45:58Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:58Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/php.13410-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206026-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206026-
Descrição: dc.descriptionSinglet oxygen (1O2) is the “active principle” in photodynamic therapy. Taurine chloramine (Tau-NHCl) and hydrogen peroxide (H2O2) are well-tolerated and widely used antiseptics. Due to its mild oxidizing features and stability, Tau-NHCl can be directly used to treat skin diseases. We found that a diluted aqueous mixture of Tau-NHCl and H2O2 acts as a slow and long-lasting potential source of 1O2. The reactions were studied by luminol-enhanced chemiluminescence. Evidence of the formation of 1O2 was obtained using deuterium oxide, sodium azide and 9,10-Anthracenediyl-bis(methylene)dimalonic acid, a chemical trap of 1O2. The reaction was optimized, and a mechanism was proposed, including theoretical calculations at B3LYP/6-311++G(3df,2p) level of theory, adding D3Bj empirical dispersion and SMD (Water) solvent effects. Chloramines produced by the reactions between HOCl and L-alanine, 3-amino-1-propanesulfonic acid and gamma-aminobutyric acid were also prepared, and their reactivity and stability were compared with Tau-NHCl. We found that Tau-NHCl is more stable and adequate for the production of 1O2. In conclusion, we propose applying these drugs combination as a potential source of 1O2 with applications for skin diseases treatment.-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences UNESP - São Paulo State University-
Descrição: dc.descriptionDepartment of Physical Chemistry Institute of Chemistry Campinas State University (UNICAMP)-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences UNESP - São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationPhotochemistry and Photobiology-
???dc.source???: dc.sourceScopus-
Título: dc.titleTaurine Chloramine and Hydrogen Peroxide as a Potential Source of Singlet Oxygen for Topical Application-
Tipo de arquivo: dc.typelivro digital-
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