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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Estadual de Campinas (UNICAMP) | - |
Autor(es): dc.creator | Ximenes, Valdecir F. [UNESP] | - |
Autor(es): dc.creator | Ximenes, Thomaz P. [UNESP] | - |
Autor(es): dc.creator | Morgon, Nelson H. | - |
Autor(es): dc.creator | de Souza, Aguinaldo R. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:45:58Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:45:58Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1111/php.13410 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/206026 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/206026 | - |
Descrição: dc.description | Singlet oxygen (1O2) is the “active principle” in photodynamic therapy. Taurine chloramine (Tau-NHCl) and hydrogen peroxide (H2O2) are well-tolerated and widely used antiseptics. Due to its mild oxidizing features and stability, Tau-NHCl can be directly used to treat skin diseases. We found that a diluted aqueous mixture of Tau-NHCl and H2O2 acts as a slow and long-lasting potential source of 1O2. The reactions were studied by luminol-enhanced chemiluminescence. Evidence of the formation of 1O2 was obtained using deuterium oxide, sodium azide and 9,10-Anthracenediyl-bis(methylene)dimalonic acid, a chemical trap of 1O2. The reaction was optimized, and a mechanism was proposed, including theoretical calculations at B3LYP/6-311++G(3df,2p) level of theory, adding D3Bj empirical dispersion and SMD (Water) solvent effects. Chloramines produced by the reactions between HOCl and L-alanine, 3-amino-1-propanesulfonic acid and gamma-aminobutyric acid were also prepared, and their reactivity and stability were compared with Tau-NHCl. We found that Tau-NHCl is more stable and adequate for the production of 1O2. In conclusion, we propose applying these drugs combination as a potential source of 1O2 with applications for skin diseases treatment. | - |
Descrição: dc.description | Department of Chemistry Faculty of Sciences UNESP - São Paulo State University | - |
Descrição: dc.description | Department of Physical Chemistry Institute of Chemistry Campinas State University (UNICAMP) | - |
Descrição: dc.description | Department of Chemistry Faculty of Sciences UNESP - São Paulo State University | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Photochemistry and Photobiology | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Taurine Chloramine and Hydrogen Peroxide as a Potential Source of Singlet Oxygen for Topical Application | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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