Mechanochemical synthesis, thermoanalytical study and characterization of new multicomponent solid forms of norfloxacin with saccharin

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorSchool of Pharmacy-
Autor(es): dc.creatorFerreira, Patrícia Osório [UNESP]-
Autor(es): dc.creatorde Moura, Aniele [UNESP]-
Autor(es): dc.creatorde Almeida, Amanda Cosmo [UNESP]-
Autor(es): dc.creatordos Santos, Éverton Carvalho [UNESP]-
Autor(es): dc.creatorKogawa, Ana Carolina-
Autor(es): dc.creatorCaires, Flávio Junior [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:45:57Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:57Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10973-021-10658-w-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/206024-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/206024-
Descrição: dc.descriptionCocrystallization is a very efficient strategy to improve the physicochemical properties of bioactive agents. A new norfloxacin (NOR)–saccharin cocrystal and a cocrystal–solvate were synthesized through the mechanochemical method (neat and liquid-assisted grinding), and the characterization was performed by thermal analysis (TG–DTA, DSC and DSC microscopy), infrared vibrational spectroscopy and powder X-ray diffraction. Moreover, solubility experiments carried out in water and buffer solutions (pH 3.0, 6.1 and 8.5) showed that norfloxacin has an aqueous solubility 3.5 times higher when cocrystallized with saccharin than in its pristine state, and an inverted pH-dependency compared to NOR alone (2 times higher in 6.1, slightly increase in pH 3.0, and a decrease of 0.7 times in 8.5 buffer solution). Furthermore, the solvate–cocrystal has a water solubility 2.3 times higher than NOR and the same solubility in 6.1 buffer solution than the cocrystal (2 times higher than NOR alone).-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Chemistry-
Descrição: dc.descriptionSchool of Science Chemistry Department São Paulo State University (UNESP)-
Descrição: dc.descriptionFederal University of Goias (UFG) School of Pharmacy-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Chemistry-
Descrição: dc.descriptionSchool of Science Chemistry Department São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Thermal Analysis and Calorimetry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMechanochemical synthesis-
Palavras-chave: dc.subjectNorfloxacin-
Palavras-chave: dc.subjectPharmaceutical cocrystal-
Palavras-chave: dc.subjectSaccharin-
Palavras-chave: dc.subjectSolvate-
Palavras-chave: dc.subjectThermal analysis-
Título: dc.titleMechanochemical synthesis, thermoanalytical study and characterization of new multicomponent solid forms of norfloxacin with saccharin-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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