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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | University of Illinois at Chicago | - |
Autor(es): dc.creator | Brandini, Daniela A. [UNESP] | - |
Autor(es): dc.creator | Takamiya, Aline S. [UNESP] | - |
Autor(es): dc.creator | Thakkar, Pari | - |
Autor(es): dc.creator | Schaller, Samantha | - |
Autor(es): dc.creator | Rahat, Rani | - |
Autor(es): dc.creator | Naqvi, Afsar R. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:45:51Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:45:51Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1002/rmv.2226 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/205983 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/205983 | - |
Descrição: dc.description | The coronavirus disease 2019 (Covid-19) is a viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that clinically affects multiple organs of the human body. Cells in the oral cavity express viral entry receptor angiotensin-converting enzyme 2 that allows viral replication and may cause tissue inflammation and destruction. Recent studies have reported that Covid-19 patients present oral manifestations with multiple clinical aspects. In this review, we aim to summarise main signs and symptoms of Covid-19 in the oral cavity, its possible association with oral diseases, and the plausible underlying mechanisms of hyperinflammation reflecting crosstalk between Covid-19 and oral diseases. Ulcers, blisters, necrotising gingivitis, opportunistic coinfections, salivary gland alterations, white and erythematous plaques and gustatory dysfunction were the most reported clinical oral manifestations in patients with Covid-19. In general, the lesions appear concomitant with the loss of smell and taste. Multiple reports show evidences of necrotic/ulcerative gingiva, oral blisters and hypergrowth of opportunistic oral pathogens. SARS-CoV-2 exhibits tropism for endothelial cells and Covid-19-mediated endotheliitis can not only promote inflammation in oral tissues but can also facilitate virus spread. In addition, elevated levels of proinflammatory mediators in patients with Covid-19 and oral infectious disease can impair tissue homeostasis and cause delayed disease resolution. This suggests potential crosstalk of immune-mediated pathways underlying pathogenesis. Interestingly, few reports suggest recurrent herpetic lesions and higher bacterial growth in Covid-19 subjects, indicating SARS-CoV-2 and oral virus/bacteria interaction. Larger cohort studies comparing SARS-CoV-2 negative and positive subjects will reveal oral manifestation of the virus on oral health and its role in exacerbating oral infection. | - |
Descrição: dc.description | Department of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Mucosal Immunology Lab College of Dentistry University of Illinois at Chicago | - |
Descrição: dc.description | Department of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Reviews in Medical Virology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Covid-19 | - |
Palavras-chave: dc.subject | cytokines | - |
Palavras-chave: dc.subject | inflammation | - |
Palavras-chave: dc.subject | oral diseases | - |
Palavras-chave: dc.subject | SARS-CoV-2 | - |
Título: dc.title | Covid-19 and oral diseases: Crosstalk, synergy or association? | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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