Covid-19 and oral diseases: Crosstalk, synergy or association?

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Illinois at Chicago-
Autor(es): dc.creatorBrandini, Daniela A. [UNESP]-
Autor(es): dc.creatorTakamiya, Aline S. [UNESP]-
Autor(es): dc.creatorThakkar, Pari-
Autor(es): dc.creatorSchaller, Samantha-
Autor(es): dc.creatorRahat, Rani-
Autor(es): dc.creatorNaqvi, Afsar R.-
Data de aceite: dc.date.accessioned2022-02-22T00:45:51Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:51Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/rmv.2226-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205983-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205983-
Descrição: dc.descriptionThe coronavirus disease 2019 (Covid-19) is a viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that clinically affects multiple organs of the human body. Cells in the oral cavity express viral entry receptor angiotensin-converting enzyme 2 that allows viral replication and may cause tissue inflammation and destruction. Recent studies have reported that Covid-19 patients present oral manifestations with multiple clinical aspects. In this review, we aim to summarise main signs and symptoms of Covid-19 in the oral cavity, its possible association with oral diseases, and the plausible underlying mechanisms of hyperinflammation reflecting crosstalk between Covid-19 and oral diseases. Ulcers, blisters, necrotising gingivitis, opportunistic coinfections, salivary gland alterations, white and erythematous plaques and gustatory dysfunction were the most reported clinical oral manifestations in patients with Covid-19. In general, the lesions appear concomitant with the loss of smell and taste. Multiple reports show evidences of necrotic/ulcerative gingiva, oral blisters and hypergrowth of opportunistic oral pathogens. SARS-CoV-2 exhibits tropism for endothelial cells and Covid-19-mediated endotheliitis can not only promote inflammation in oral tissues but can also facilitate virus spread. In addition, elevated levels of proinflammatory mediators in patients with Covid-19 and oral infectious disease can impair tissue homeostasis and cause delayed disease resolution. This suggests potential crosstalk of immune-mediated pathways underlying pathogenesis. Interestingly, few reports suggest recurrent herpetic lesions and higher bacterial growth in Covid-19 subjects, indicating SARS-CoV-2 and oral virus/bacteria interaction. Larger cohort studies comparing SARS-CoV-2 negative and positive subjects will reveal oral manifestation of the virus on oral health and its role in exacerbating oral infection.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionMucosal Immunology Lab College of Dentistry University of Illinois at Chicago-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationReviews in Medical Virology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCovid-19-
Palavras-chave: dc.subjectcytokines-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectoral diseases-
Palavras-chave: dc.subjectSARS-CoV-2-
Título: dc.titleCovid-19 and oral diseases: Crosstalk, synergy or association?-
Aparece nas coleções:Repositório Institucional - Unesp

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