Peptide Profile of Zebrafish Brain in a 6-OHDA-Induced Parkinson Model

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorFiametti, Louise Oliveira [UNESP]-
Autor(es): dc.creatorCorrea, Claudia Neves [UNESP]-
Autor(es): dc.creatorCastro, Leandro Mantovani De [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:45:45Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:45Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1089/zeb.2020.1945-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205950-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205950-
Descrição: dc.descriptionParkinson's disease (PD) is a chronic neurodegenerative disorder mainly attributed to the progressive loss of dopaminergic neurons in the substantia nigra, which leads to uncontrolled voluntary movements causing tremors, postural instability, joint stiffness, and speech and locomotion difficulties, among other symptoms. Previous studies have shown the participation of specific peptides in neurodegenerative diseases. In this context, the present work analyzed changes in the peptide profile in zebrafish brain induced to parkinsonian conditions with 6-hydroxydopamine, using isotopic labeling techniques plus mass spectrometry. These analyses allowed the relative quantitation and identification of 118 peptides. Of these, nine peptides showed significant changes, one peptide was increased and eight decreased. The most altered sequences were fragment of cytosolic and extracellular proteins related to lipid metabolism and dynamic cytoskeleton. These results open new perspectives of study about the function of peptides in PD.-
Descrição: dc.descriptionBioscience Institute Sao Paulo State University (UNESP)-
Descrição: dc.descriptionBiodiversity of Coastal Environments Postgraduate Program Bioscience Institute Sao Paulo State University (UNESP)-
Descrição: dc.descriptionBioscience Institute Sao Paulo State University (UNESP)-
Descrição: dc.descriptionBiodiversity of Coastal Environments Postgraduate Program Bioscience Institute Sao Paulo State University (UNESP)-
Formato: dc.format55-65-
Idioma: dc.languageen-
Relação: dc.relationZebrafish-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectmass spectrometry-
Palavras-chave: dc.subjectneurodegenerative disease-
Palavras-chave: dc.subjectpeptidomics-
Palavras-chave: dc.subjectzebrafish-
Título: dc.titlePeptide Profile of Zebrafish Brain in a 6-OHDA-Induced Parkinson Model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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