Rhipicephalus sanguineus salivary gland extract as a source of immunomodulatory molecules

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorPereira, Melissa Carolina [UNESP]-
Autor(es): dc.creatorNodari, Elen Fernanda [UNESP]-
Autor(es): dc.creatorde Abreu, Marina Rodrigues [UNESP]-
Autor(es): dc.creatorPaiatto, Lisiery Negrini-
Autor(es): dc.creatorSimioni, Patrícia Ucelli-
Autor(es): dc.creatorCamargo-Mathias, Maria Izabel [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:45:45Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:45Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10493-021-00591-w-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205947-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205947-
Descrição: dc.descriptionRhipicephalus sanguineus sensu lato (s.l.), popularly known as ‘brown dog tick’, is the primary vector of pathogens affecting dogs worldwide. To enter the host’s organism, these pathogens utilise the anticoagulant, antiplatelet, anti-inflammatory and immunomodulatory actions of compounds present in the tick’s saliva; such compounds are released by the ectoparasite in order to attach and feed on dogs. Nitric oxide (NO) is one of the regulatory factors in inflammation, apoptosis and immunomodulation. Here, we evaluated the in vitro activity of salivary gland extract of female dog ticks on the macrophage-derived J774 cell line, with and without lipopolysaccharide (LPS) stimulation. Cultures were evaluated for possible morphological alterations caused by exposure to the extract. There was no apparent in vitro cytotoxicity of the extract. Also, the NO secretory response in the non-LPS-stimulated cells was not inhibited. On the other hand, the extract presented modulatory action in the cultures of LPS-stimulated cells at a concentration of 0.1 μg/mL, possibly through macrophage activation, and induced a significant decrease in NO secretion. These results confirm the modulatory potential of bioactive molecules in the salivary glands of R. sanguineus ticks.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences São Paulo State University – UNESP-
Descrição: dc.descriptionDepartment of Genetics Evolution and Bioagents Institute of Biology University of Campinas – UNICAMP-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences São Paulo State University – UNESP-
Descrição: dc.descriptionFAPESP: 2014/02843-8-
Descrição: dc.descriptionFAPESP: 2015/20745-6-
Descrição: dc.descriptionFAPESP: 2018/2999-9-
Descrição: dc.descriptionFAPESP: 2019/02831-3-
Descrição: dc.descriptionCNPq: 300625/2012-0-
Formato: dc.format387-398-
Idioma: dc.languageen-
Relação: dc.relationExperimental and Applied Acarology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEctoparasite-host relationships-
Palavras-chave: dc.subjectNitric oxide-
Palavras-chave: dc.subjectSaliva-
Palavras-chave: dc.subjectTicks-
Título: dc.titleRhipicephalus sanguineus salivary gland extract as a source of immunomodulatory molecules-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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