Engineering multifunctional bactericidal nanofibers for abdominal hernia repair

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Autor(es): dc.contributorHarvard Medical School-
Autor(es): dc.contributorHarvard University ‒ Massachusetts Institute of Technology-
Autor(es): dc.contributorNortheastern University-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorBrasil University-
Autor(es): dc.contributorUFPI - Federal University of Piaui-
Autor(es): dc.contributorFederal University of Piaui-
Autor(es): dc.contributorMIT-
Autor(es): dc.creatorAfewerki, Samson-
Autor(es): dc.creatorBassous, Nicole-
Autor(es): dc.creatorHarb, Samarah Vargas [UNESP]-
Autor(es): dc.creatorCorat, Marcus Alexandre F.-
Autor(es): dc.creatorMaharjan, Sushila-
Autor(es): dc.creatorRuiz-Esparza, Guillermo U.-
Autor(es): dc.creatorde Paula, Mirian M. M.-
Autor(es): dc.creatorWebster, Thomas J.-
Autor(es): dc.creatorTim, Carla Roberta-
Autor(es): dc.creatorViana, Bartolomeu Cruz-
Autor(es): dc.creatorWang, Danquan-
Autor(es): dc.creatorWang, Xichi-
Autor(es): dc.creatorMarciano, Fernanda Roberta-
Autor(es): dc.creatorLobo, Anderson Oliveira-
Data de aceite: dc.date.accessioned2022-02-22T00:45:41Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:41Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s42003-021-01758-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205924-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205924-
Descrição: dc.descriptionThe engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile and cheap fabrication technology, is a great challenge. Moreover, hernia, which is when organ is pushed through an opening in the muscle or adjacent tissue due to damage of tissue structure or function, is a dire clinical challenge that currently needs surgery for recovery. Nevertheless, post-surgical hernia complications, like infection, fibrosis, tissue adhesions, scaffold rejection, inflammation, and recurrence still remain important clinical problems. Herein, through an integrated electrospinning, plasma treatment and direct surface modification strategy, multifunctional bactericidal nanofibers were engineered showing optimal properties for hernia repair. The nanofibers displayed good bactericidal activity, low inflammatory response, good biodegradation, as well as optimal collagen-, stress fiber- and blood vessel formation and associated tissue ingrowth in vivo. The disclosed engineering strategy serves as a prominent platform for the design of other multifunctional materials for various biomedical challenges.-
Descrição: dc.descriptionDivision of Engineering in Medicine Department of Medicine Brigham and Women’s Hospital Harvard Medical School-
Descrição: dc.descriptionDivision of Health Sciences and Technology Harvard University ‒ Massachusetts Institute of Technology-
Descrição: dc.descriptionNanomedicine Laboratory Department of Chemical Engineering Northeastern University-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionMultidisciplinary Center for Biological Research University of Campinas (UNICAMP)-
Descrição: dc.descriptionBrasil University-
Descrição: dc.descriptionLIMAV - Interdisciplinary Laboratory for Advanced Materials Materials Science & Engineering Graduate Program UFPI - Federal University of Piaui-
Descrição: dc.descriptionDepartment of Physics Federal University of Piaui-
Descrição: dc.descriptionDepartment of Chemistry Massachusetts Institute of Technology MIT-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationCommunications Biology-
???dc.source???: dc.sourceScopus-
Título: dc.titleEngineering multifunctional bactericidal nanofibers for abdominal hernia repair-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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