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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Harvard Medical School | - |
Autor(es): dc.contributor | Harvard University ‒ Massachusetts Institute of Technology | - |
Autor(es): dc.contributor | Northeastern University | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Universidade Estadual de Campinas (UNICAMP) | - |
Autor(es): dc.contributor | Brasil University | - |
Autor(es): dc.contributor | UFPI - Federal University of Piaui | - |
Autor(es): dc.contributor | Federal University of Piaui | - |
Autor(es): dc.contributor | MIT | - |
Autor(es): dc.creator | Afewerki, Samson | - |
Autor(es): dc.creator | Bassous, Nicole | - |
Autor(es): dc.creator | Harb, Samarah Vargas [UNESP] | - |
Autor(es): dc.creator | Corat, Marcus Alexandre F. | - |
Autor(es): dc.creator | Maharjan, Sushila | - |
Autor(es): dc.creator | Ruiz-Esparza, Guillermo U. | - |
Autor(es): dc.creator | de Paula, Mirian M. M. | - |
Autor(es): dc.creator | Webster, Thomas J. | - |
Autor(es): dc.creator | Tim, Carla Roberta | - |
Autor(es): dc.creator | Viana, Bartolomeu Cruz | - |
Autor(es): dc.creator | Wang, Danquan | - |
Autor(es): dc.creator | Wang, Xichi | - |
Autor(es): dc.creator | Marciano, Fernanda Roberta | - |
Autor(es): dc.creator | Lobo, Anderson Oliveira | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:45:41Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:45:41Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-11-30 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1038/s42003-021-01758-2 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/205924 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/205924 | - |
Descrição: dc.description | The engineering of multifunctional surgical bactericidal nanofibers with inherent suitable mechanical and biological properties, through facile and cheap fabrication technology, is a great challenge. Moreover, hernia, which is when organ is pushed through an opening in the muscle or adjacent tissue due to damage of tissue structure or function, is a dire clinical challenge that currently needs surgery for recovery. Nevertheless, post-surgical hernia complications, like infection, fibrosis, tissue adhesions, scaffold rejection, inflammation, and recurrence still remain important clinical problems. Herein, through an integrated electrospinning, plasma treatment and direct surface modification strategy, multifunctional bactericidal nanofibers were engineered showing optimal properties for hernia repair. The nanofibers displayed good bactericidal activity, low inflammatory response, good biodegradation, as well as optimal collagen-, stress fiber- and blood vessel formation and associated tissue ingrowth in vivo. The disclosed engineering strategy serves as a prominent platform for the design of other multifunctional materials for various biomedical challenges. | - |
Descrição: dc.description | Division of Engineering in Medicine Department of Medicine Brigham and Women’s Hospital Harvard Medical School | - |
Descrição: dc.description | Division of Health Sciences and Technology Harvard University ‒ Massachusetts Institute of Technology | - |
Descrição: dc.description | Nanomedicine Laboratory Department of Chemical Engineering Northeastern University | - |
Descrição: dc.description | Institute of Chemistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Multidisciplinary Center for Biological Research University of Campinas (UNICAMP) | - |
Descrição: dc.description | Brasil University | - |
Descrição: dc.description | LIMAV - Interdisciplinary Laboratory for Advanced Materials Materials Science & Engineering Graduate Program UFPI - Federal University of Piaui | - |
Descrição: dc.description | Department of Physics Federal University of Piaui | - |
Descrição: dc.description | Department of Chemistry Massachusetts Institute of Technology MIT | - |
Descrição: dc.description | Institute of Chemistry São Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Communications Biology | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | Engineering multifunctional bactericidal nanofibers for abdominal hernia repair | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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