Nanoporous silk films with capillary action and size-exclusion capacity for sensitive glucose determination in whole blood

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Autor(es): dc.contributorCSIC)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversitat Autònoma de Barcelona Bellaterra (Barcelona)-
Autor(es): dc.contributorInstituto Murciano de Investigación y Desarrollo Agrario y Alimentario (IMIDA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorTufts University-
Autor(es): dc.creatorMárquez, Augusto-
Autor(es): dc.creatorSantos, Moliria V.-
Autor(es): dc.creatorGuirado, Gonzalo-
Autor(es): dc.creatorMoreno, Alex-
Autor(es): dc.creatorAznar-Cervantes, Salvador D.-
Autor(es): dc.creatorCenis, Jose Luis-
Autor(es): dc.creatorSantagneli, Silvia H. [UNESP]-
Autor(es): dc.creatorDomínguez, Carlos-
Autor(es): dc.creatorOmenetto, Fiorenzo G.-
Autor(es): dc.creatorMuñoz-Berbel, Xavier-
Data de aceite: dc.date.accessioned2022-02-22T00:45:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:32Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-02-06-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/d0lc00702a-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205874-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205874-
Descrição: dc.descriptionIn optical biosensing, silk fibroin (SF) appears as a promising alternative where other materials, such as paper, find limitations. Besides its excellent optical properties and unmet capacity to stabilize biomacromolecules, SF in test strips exhibits additional functions,i.e.capillary pumping activity of 1.5 mm s−1, capacity to filter blood cells thanks to its small, but tuneable, porosity and enhanced biosensing sensitivity. The bulk functionalization of SF with the enzymes glucose oxidase and peroxidase and the mediator ABTS produces colourless and transparent SF films that respond to blood glucose increasing 2.5 times the sensitivity of conventional ABTS-based assays. This enhanced sensitivity results from the formation of SF-ABTS complexes, where SF becomes part of the bioassay. Additionally, SF films triple the durability of most stable cellulose-based sensors. Although demonstrated for glucose, SF microfluidic test strips may incorporate other optical bioassays,e.g.immunoassays, with the aim of transferring them from central laboratories to the place of patient's care.-
Descrição: dc.descriptionInstituto de Microelectrónica de Barcelona (IMB-CNM CSIC)-
Descrição: dc.descriptionSão Carlos Institute of Physics University of São Paulo-
Descrição: dc.descriptionDepartament de Química Universitat Autònoma de Barcelona Bellaterra (Barcelona)-
Descrição: dc.descriptionInstituto Murciano de Investigación y Desarrollo Agrario y Alimentario (IMIDA)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSilklab Department of Biomedical Engineering Tufts University-
Descrição: dc.descriptionDepartment of Electrical and Computer Engineering Tufts University-
Descrição: dc.descriptionDepartment of Physics Tufts University-
Descrição: dc.descriptionLaboratory for Living Devices Tufts University-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Formato: dc.format608-615-
Idioma: dc.languageen-
Relação: dc.relationLab on a Chip-
???dc.source???: dc.sourceScopus-
Título: dc.titleNanoporous silk films with capillary action and size-exclusion capacity for sensitive glucose determination in whole blood-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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