Surface-Directed Mineralization of Fibrous Collagen Scaffolds in Simulated Body Fluid for Tissue Engineering Applications

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorMarquette University School of Dentistry-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorBim-Júnior, Odair [UNESP]-
Autor(es): dc.creatorCurylofo-Zotti, Fabiana-
Autor(es): dc.creatorReis, Mariana-
Autor(es): dc.creatorAlania, Yvette-
Autor(es): dc.creatorLisboa-Filho, Paulo N. [UNESP]-
Autor(es): dc.creatorBedran-Russo, Ana K.-
Data de aceite: dc.date.accessioned2022-02-22T00:45:30Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:30Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acsabm.0c01507-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205857-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205857-
Descrição: dc.descriptionThe use of polymer additives that stabilize fluidic amorphous calcium phosphate is key to obtaining intrafibrillar mineralization of collagen in vitro. On the other hand, this biomimetic approach inhibits the nucleation of mineral crystals in unconfined extrafibrillar spaces, that is, extrafibrillar mineralization. The extrafibrillar mineral content is a significant feature to replicate from hard connective tissues such as bone and dentin as it contributes to the final microarchitecture and mechanical stiffness of the biomineral composite. Herein, we report a straightforward route to produce densely mineralized collagenous composites via a surface-directed process devoid of the aid of polymer additives. Simulated body fluid (1×) is employed as a biomimetic crystallizing medium, following a preloading procedure on the collagen surface to quickly generate the amorphous precursor species required to initiate matrix mineralization. This approach consistently leads to the formation of extrafibrillar bioactive minerals in bulk collagen scaffolds, which may offer an advantage in the production of osteoconductive collagen-apatite materials for tissue engineering and repair purposes.-
Descrição: dc.descriptionDepartment of General Dental Sciences Marquette University School of Dentistry-
Descrição: dc.descriptionDepartment of Physics School of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry of Ribeirão Preto University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Physics School of Sciences São Paulo State University (UNESP)-
Formato: dc.format2514-2522-
Idioma: dc.languageen-
Relação: dc.relationACS Applied Bio Materials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectamorphous precursor-
Palavras-chave: dc.subjectapatite-
Palavras-chave: dc.subjectmineralization-
Palavras-chave: dc.subjectnanofibrous scaffolds-
Palavras-chave: dc.subjecttype-I collagen-
Título: dc.titleSurface-Directed Mineralization of Fibrous Collagen Scaffolds in Simulated Body Fluid for Tissue Engineering Applications-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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