Thermal study and characterization of new cocrystals of ciprofloxacin with picolinic acid

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorTorquetti, Carolina [UNESP]-
Autor(es): dc.creatorFerreira, Patrícia Osório [UNESP]-
Autor(es): dc.creatorde Almeida, Amanda Cosmo [UNESP]-
Autor(es): dc.creatorFernandes, Richard Perosa [UNESP]-
Autor(es): dc.creatorCaires, Flávio Junior [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:45:29Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:29Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10973-020-10479-3-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205850-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205850-
Descrição: dc.descriptionThis article describes the mechanochemical synthesis (liquid-assisted grinding (LAG) and neat grinding (NG)), characterization and thermoanalytical study of new cocrystals of ciprofloxacin (CIP) with picolinic acid (PCA) in a 1:1 molar ratio. Characterization was performed through thermoanalytical techniques (differential scanning calorimetry (DSC), simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC)), X-ray powder diffraction (XRPD) and infrared spectroscopy (IR). The thermoanalytical study, together with the XRPD and IR techniques, confirmed the formation of new cocrystal and helped to understand its formation. From the LAG method, using ethanol as a solvent, a cocrystal solvate was obtained. The NG method, together with thermal stress, favored obtaining the cocrystal through a coamorphous intermediate phase. Solubility study of all new materials showed an increase in CIP concentration for the cocrystals compared to pure drug.-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Science Chemistry Department-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Chemistry Post-Graduate Program in Chemistry-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Science Chemistry Department-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Chemistry Post-Graduate Program in Chemistry-
Idioma: dc.languageen-
Relação: dc.relationJournal of Thermal Analysis and Calorimetry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCiprofloxacin-
Palavras-chave: dc.subjectCoamorphous-
Palavras-chave: dc.subjectCocrystal-
Palavras-chave: dc.subjectCocrystal solvate-
Palavras-chave: dc.subjectMechanochemistry-
Palavras-chave: dc.subjectThermal analysis-
Título: dc.titleThermal study and characterization of new cocrystals of ciprofloxacin with picolinic acid-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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