Coumarin Derivatives in Inflammatory Bowel Disease

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorDi Stasi, Luiz C. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:45:24Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:24Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules26020422-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205821-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205821-
Descrição: dc.descriptionInflammatory bowel disease (IBD) is a non-communicable disease characterized by a chronic inflammatory process of the gut and categorized into Crohn's disease and ulcerative colitis, both currently without definitive pharmacological treatment and cure. The unclear etiology of IBD is a limiting factor for the development of new drugs and explains the high frequency of refractory patients to current drugs, which are also related to various adverse effects, mainly after long-term use. Dissatisfaction with current therapies has promoted an increased interest in new pharmacological approaches using natural products. Coumarins comprise a large class of natural phenolic compounds found in fungi, bacteria, and plants. Coumarin and its derivatives have been reported as antioxidant and anti-inflammatory compounds, potentially useful as complementary therapy of the IBD. These compounds produce protective effects in intestinal inflammation through different mechanisms and signaling pathways, mainly modulating immune and inflammatory responses, and protecting against oxidative stress, a central factor for IBD development. In this review, we described the main coumarin derivatives reported as intestinal anti-inflammatory products and its available pharmacodynamic data that support the protective effects of these products in the acute and subchronic phase of intestinal inflammation.-
Descrição: dc.descriptionLaboratory of Phytomedicines Pharmacology Biotechnology (PhytoPharmaTech) Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Phytomedicines Pharmacology Biotechnology (PhytoPharmaTech) Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationMolecules (Basel, Switzerland)-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcomplementary therapies-
Palavras-chave: dc.subjectcoumarin-
Palavras-chave: dc.subjectCrohn’s disease-
Palavras-chave: dc.subjectglutathione-
Palavras-chave: dc.subjectinflammatory bowel disease-
Palavras-chave: dc.subjectintestinal inflammation-
Palavras-chave: dc.subjectisocoumarin-
Palavras-chave: dc.subjectoxidative stress-
Palavras-chave: dc.subjectulcerative colitis-
Título: dc.titleCoumarin Derivatives in Inflammatory Bowel Disease-
Aparece nas coleções:Repositório Institucional - Unesp

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