Resistance mesenteric arteries display hypercontractility in the resolution time of Strongyloides venezuelensis infection

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Goias-
Autor(es): dc.contributorFederal University of Mato Grosso-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorDela Justina, Vanessa-
Autor(es): dc.creatorGama, Loyane Almeida [UNESP]-
Autor(es): dc.creatorSchönholzer, Tatiane-
Autor(es): dc.creatorBressan, Alecsander F.-
Autor(es): dc.creatorLima, Victor Vitorino-
Autor(es): dc.creatorAmerico, Madileine F. [UNESP]-
Autor(es): dc.creatorGiachini, Fernanda R.-
Data de aceite: dc.date.accessioned2022-02-22T00:45:15Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:15Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.exppara.2021.108078-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205775-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205775-
Descrição: dc.descriptionThe blood flow in the mesenteric region is crucial for nutrient absorption and immune response in the gastrointestinal tract. The presence of nematodes or their excreted/secreted products seems to provoke vascular dysfunction. However, it is unclear whether and how the intestinal nematodes with habitat in the intestinal niche could affect the mesenteric vascular resistance. In this study, male Wistar rats were infected with 2000 larvae of S. venezuelensis, and experiments were conducted at 0 (non-infected control), 10 or 30 days post-infection (DPI). Eggs were counted in rats’ feces and adult worms recovered from the small intestine. Second- or third-order mesenteric arteries were extracted for concentration-response curves (CRC) to phenylephrine [PE; in the presence or absence of L-NAME or indomethacin] and acetylcholine. The number of eggs and adult worms were significantly higher in the 10 DPI group than those of 30 DPI group. Augmented PE-induced contraction was seen after 30 DPI compared to 10 DPI or control group. Hypercontractility to PE was partially prevented by L-NAME and wholly abolished by indomethacin incubation. Endothelium-dependent relaxation and endothelial nitric oxide synthase expression were unchanged among groups. COX-1 and COX-2 display a different pattern of expression over the infection. Hypercontractility observed in mesenteric resistance arteries in the resolution time of S. venezuelensis infection may represent systemic damage, which can generate significant cardiovascular and gastrointestinal repercussions.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Mato Grosso-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionInstitute of Biological Sciences Federal University of Goias-
Descrição: dc.descriptionInstitute of Biological Sciences and Health Federal University of Mato Grosso-
Descrição: dc.descriptionDepartment of Pharmacology Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University – UNESP-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University – UNESP-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Mato Grosso: 0324552/2018-
Descrição: dc.descriptionCNPq: 303866/2014–4-
Descrição: dc.descriptionCNPq: 306166/2019–4-
Descrição: dc.descriptionCNPq: 445777/2014–1-
Idioma: dc.languageen-
Relação: dc.relationExperimental Parasitology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOX-
Palavras-chave: dc.subjecteNOS-
Palavras-chave: dc.subjectIntestinal parasites-
Palavras-chave: dc.subjectProstaglandins-
Título: dc.titleResistance mesenteric arteries display hypercontractility in the resolution time of Strongyloides venezuelensis infection-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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