Analytical profile and antioxidant and anti-inflammatory activities of the enriched polyphenol fractions isolated from bergamot fruit and leave

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Autor(es): dc.contributorUniversity of Milan-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorCentro Cardiologico Monzino-IRCCS-
Autor(es): dc.contributorH&AD Srl-
Autor(es): dc.contributorUniversity “Magna Graecia” of Catanzaro-
Autor(es): dc.contributorPlantexresearch Srl-
Autor(es): dc.creatorBaron, Giovanna-
Autor(es): dc.creatorAltomare, Alessandra-
Autor(es): dc.creatorMol, Marco-
Autor(es): dc.creatorGarcia, Jessica Leite [UNESP]-
Autor(es): dc.creatorCorrea, Camila [UNESP]-
Autor(es): dc.creatorRaucci, Angela-
Autor(es): dc.creatorMancinelli, Luigi-
Autor(es): dc.creatorMazzotta, Sarah-
Autor(es): dc.creatorFumagalli, Laura-
Autor(es): dc.creatorTrunfio, Giuseppe-
Autor(es): dc.creatorTucci, Luigi-
Autor(es): dc.creatorLombardo, Elena-
Autor(es): dc.creatorMalara, Domenico-
Autor(es): dc.creatorJanda, Elzbieta-
Autor(es): dc.creatorMollace, Vincenzo-
Autor(es): dc.creatorCarini, Marina-
Autor(es): dc.creatorBombardelli, Ezio-
Autor(es): dc.creatorAldini, Giancarlo-
Data de aceite: dc.date.accessioned2022-02-22T00:45:13Z-
Data de disponibilização: dc.date.available2022-02-22T00:45:13Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antiox10020141-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205764-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205764-
Descrição: dc.descriptionThe aim of the study is to compare the qualitative and semi-quantitative profile of the polyphenol fraction purified from the leaf (BLPF) and fruit (BFPF) of bergamot (Citrus bergamia), and to evaluate their antioxidant and anti-inflammatory activity. The analytical qualitative profile was carried out by LC-ESI/MS using three different approaches: targeted (searching analytes al-ready reported in bergamot extract), semi-targeted (a selective search of 3-hydroxy-3-methylglu-tarate [HMG] derivatives involved in the cholesterol reducing activity of BPF) and untargeted. A total number of 108 compounds were identified by using the three approaches, 100 of which are present in both the extracts thus demonstrating a good qualitative overlapping of polyphenols between the two extracts. The antioxidant activity was higher for BLPF in respect to BFPF but when normalized in respect to the polyphenol content they were almost overlapping. Both the extracts were found to dose dependently inhibit cell inflammation stimulated with IL-1α. In conclusion, the comparison of the qualitative and quantitative profile of polyphenols as well as of the antioxidant and anti-inflammatory activity of bergamot leaf and fruit well indicates that leaf is a valid source of bergamot polyphenol extraction and an even richer source of polyphenol in respect to the fruit.-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences University of Milan-
Descrição: dc.descriptionMedical School Sao Paulo State University (Unesp)-
Descrição: dc.descriptionExperimental Cardio-oncology and Cardiovascular Aging Unit Centro Cardiologico Monzino-IRCCS, Via Carlo Parea, 4-
Descrição: dc.descriptionH&AD Srl-
Descrição: dc.descriptionDepartment of Health Sciences University “Magna Graecia” of Catanzaro-
Descrição: dc.descriptionPlantexresearch Srl-
Descrição: dc.descriptionMedical School Sao Paulo State University (Unesp)-
Formato: dc.format1-27-
Idioma: dc.languageen-
Relação: dc.relationAntioxidants-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntioxidant-
Palavras-chave: dc.subjectCholesterol-
Palavras-chave: dc.subjectCitrus bergamia-
Palavras-chave: dc.subjectHigh-resolution mass spectrometry-
Palavras-chave: dc.subjectHMG-
Palavras-chave: dc.subjectInflam-mation-
Palavras-chave: dc.subjectMetabolic syndrome-
Palavras-chave: dc.subjectPolyphenols-
Título: dc.titleAnalytical profile and antioxidant and anti-inflammatory activities of the enriched polyphenol fractions isolated from bergamot fruit and leave-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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