The impact of hypothermic pulsatile machine perfusion versus static cold storage: A donor-matched paired analysis in a scenario of high incidence of delayed kidney graft function

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Ceará-
Autor(es): dc.contributorHospital Geral de Fortaleza-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorWalter Cantídio University Hospital-
Autor(es): dc.creatorde Sandes-Freitas, Tainá Veras-
Autor(es): dc.creatorCosta, Silvana Daher-
Autor(es): dc.creatorde Andrade, Luís Gustavo Modelli [UNESP]-
Autor(es): dc.creatorGirão, Celi Melo-
Autor(es): dc.creatorFernandes, Paula Frassinetti C.B.C.-
Autor(es): dc.creatorCosta de Oliveira, Claudia Maria-
Autor(es): dc.creatorEsmeraldo, Ronaldo de Matos-
Data de aceite: dc.date.accessioned2022-02-22T00:44:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:54Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.12659/AOT.927010-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205647-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205647-
Descrição: dc.descriptionBackground: Material/Methods: Results: Conclusions: The present study analyzed the impact of hypothermic pulsatile machine perfusion (MP) following a long period of static cold (SC) storage in the peculiar Brazilian scenario of high incidence of delayed graft function (DGF), despite good donor characteristics. A retrospective analysis, with a 1-year follow-up, of 206 recipients of donor-matched paired kidneys was per-formed. Of the 206 donor kidneys, 103 were maintained exclusively in static cold storage (SC group) and 103 were kept on machine perfusion after a period of SC preservation (MP group). All donors were brain dead. Only 4.9% of the kidneys were from expanded-criteria donors. Static cold ischemia time (CIT) in the SC group was 20.8±4.1 hours vs. 15.8±6.2 hours in the MP group (P<0.001). Dynamic CIT in the MP group was 12.3±5.7 hours. MP significantly reduced DGF incidence (29.1% vs. 55.3%, P<0.001), and this effect was confirmed in multivariable analysis (OR, 1.115; 95% CI, 1.033–1.204, P=0.001). No differences were observed between the groups with regard to DGF duration, length of hospital stay, incidence of primary nonfunction and acute rejec-tion, graft loss, death, or renal function. In this Brazilian setting, MP following a long period of SC preservation was associated with reduced DGF incidence in comparison with SC storage without MP.-
Descrição: dc.descriptionDepartment of Clinical Medicine Faculty of Medicine Federal University of Ceará-
Descrição: dc.descriptionTransplant Division Hospital Geral de Fortaleza-
Descrição: dc.descriptionDepartment of Internal Medicine Paulista State University - UNESP-
Descrição: dc.descriptionTransplant Division Walter Cantídio University Hospital-
Descrição: dc.descriptionDepartment of Internal Medicine Paulista State University - UNESP-
Formato: dc.format1-7-
Idioma: dc.languageen-
Relação: dc.relationAnnals of Transplantation-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMeSH Delayed Graft Function-
Palavras-chave: dc.subjectOrgan Preservation-
Palavras-chave: dc.subjectPulsatile Flow-
Título: dc.titleThe impact of hypothermic pulsatile machine perfusion versus static cold storage: A donor-matched paired analysis in a scenario of high incidence of delayed kidney graft function-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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