Gamma-oryzanol as a potential modulator of oxidative stress and inflammation via PPAR-y in adipose tissue: a hypothetical therapeutic for cytokine storm in COVID-19?

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorBotucatu Integrated College (UNIFAC)-
Autor(es): dc.creatorFrancisqueti-Ferron, Fabiane Valentini [UNESP]-
Autor(es): dc.creatorGarcia, Jéssica Leite [UNESP]-
Autor(es): dc.creatorFerron, Artur Junio Togneri [UNESP]-
Autor(es): dc.creatorNakandakare-Maia, Erika Tiemi [UNESP]-
Autor(es): dc.creatorGregolin, Cristina Schmitt [UNESP]-
Autor(es): dc.creatorSilva, Janaina Paixão das Chagas [UNESP]-
Autor(es): dc.creatordos Santos, Klinsmann Carolo [UNESP]-
Autor(es): dc.creatorLo, Ângelo Thompson Colombo [UNESP]-
Autor(es): dc.creatorSiqueira, Juliana Silva [UNESP]-
Autor(es): dc.creatorde Mattei, Letícia [UNESP]-
Autor(es): dc.creatorde Paula, Bruno Henrique [UNESP]-
Autor(es): dc.creatorSarzi, Felipe-
Autor(es): dc.creatorSilva, Carol Cristina Vágula de Almeida [UNESP]-
Autor(es): dc.creatorMoreto, Fernando [UNESP]-
Autor(es): dc.creatorCosta, Mariane Róvero [UNESP]-
Autor(es): dc.creatorFerreira, Ana Lucia A. [UNESP]-
Autor(es): dc.creatorMinatel, Igor Otávio [UNESP]-
Autor(es): dc.creatorCorrêa, Camila Renata [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:44:40Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:40Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2020.111095-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205568-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205568-
Descrição: dc.descriptionThe literature has reported a higher prevalence of negative clinical outcomes due to Coronavirus disease 19 (COVID-19) in obese individuals. This can be explained by the cytokine storm, result from the cytokine production from both obesity and viral infection. Gamma-oryzanol (γOz) is a compound with anti-inflammatory and antioxidant activities. However, little is known about the γOz action as a possible agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). The aim of this study was to test the hypothesis that γOz attenuates the cytokine storm by stimulating PPAR-γ in the adipose tissue. Methods: Male Wistar rats were randomly divided into three experimental groups and fed ad libitum for 30 weeks with control diet (C, n = 6), high sugar-fat diet (HSF, n = 6) or high sugar-fat diet + γOz (HSF + γOz, n = 6). HSF groups also received water + sucrose (25%). The γOz dose was 0.5% in the chow. Evaluation in animals included caloric intake, body weight, adiposity index, plasma triglycerides, and HOMA-IR. In adipose tissue was evaluated: PPAR-γ gene and protein expression, inflammatory and oxidative stress parameters, and histological analysis. Results: Adipose tissue dysfunction was observed in HSF group, which presented remarkable PPAR-γ underexpression and increased levels of cytokines, other inflammatory markers and oxidative stress. The γOz treatment prevented adipose tissue dysfunction and promoted PPAR-γ overexpression. Conclusion: Natural compounds as γOz can be considered a coadjutant therapy to prevent the cytokine storm in COVID-19 patients with obesity conditions.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (Unesp) Medical School-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Bioscience-
Descrição: dc.descriptionBotucatu Integrated College (UNIFAC)-
Descrição: dc.descriptionSão Paulo State University (Unesp) Medical School-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Bioscience-
Descrição: dc.descriptionFAPESP: #2015/10626-0-
Descrição: dc.descriptionFAPESP: #2018/15294-3-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectGamma-oryzanol-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectPPAR-γ-
Título: dc.titleGamma-oryzanol as a potential modulator of oxidative stress and inflammation via PPAR-y in adipose tissue: a hypothetical therapeutic for cytokine storm in COVID-19?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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