A new phytocosmetic preparation from Thymus vulgaris stimulates adipogenesis and controls skin aging process: In vitro studies and topical effects in a double-blind placebo-controlled clinical trial

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorChemyunion Química Ltda-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorCaverzan, Jeanifer-
Autor(es): dc.creatorMussi, Lilian-
Autor(es): dc.creatorSufi, Bianca-
Autor(es): dc.creatorPadovani, Giovana-
Autor(es): dc.creatorNazato, Lucas-
Autor(es): dc.creatorCamargo, Flavio B.-
Autor(es): dc.creatorMagalhães, Wagner V.-
Autor(es): dc.creatorDi Stasi, Luiz C. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:44:35Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:35Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jocd.13818-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205531-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205531-
Descrição: dc.descriptionBackground: The use of the injectable products for soft tissue augmentation and treatment of skin aging is an uncomfortable, invasive and related to several complications, and chronic reactions, mainly after long-term application. Efforts to develop new topically active anti-aging products with fewer adverse effects are a huge challenge that should be faced. Aims: We evaluated the anti-aging effects of a phytocosmetic preparation containing Thymus vulgaris associated with lecithin (ThymLec) on the facial wrinkles, expression lines, and face oval remodeling using a double-blind placebo-controlled clinical trial and in vitro cell culture assays. Methods: A clinical trial was conducted to evaluate the effects of ThymLec 2% on the area, length, and depth of the perioral and crow's feet wrinkles, nasolabial and smile lines, as well as face oval remodeling in female volunteers using a sophisticated Bio3D Structured-light Scanner. In the in vitro studies using 3T3-L1 mouse embryonic fibroblasts, adiponectin was measured by immunoenzymatic assay, adipogenesis by the AdipoRed reagent method, and the PPAR-γ expression by RT-PCR analysis. Results: Topical treatment with ThymLec 2% reduced facial wrinkles and expression lines promoting a face oval remodeling. In the in vitro studies, ThymLec upregulated the PPAR-γ expression increasing adiponectin production and stimulating the adipogenesis process. Conclusions: The phytocosmetic preparation containing Thymus vulgaris and lecithin is an innovative and safe topical anti-aging product promoting fat tissue augmentation by adipogenesis stimulation via the upregulation of PPAR-γ expression and adiponectin production.-
Descrição: dc.descriptionResearch and Development Department Chemyunion Química Ltda-
Descrição: dc.descriptionLaboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTech) Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (Unesp)-
Descrição: dc.descriptionLaboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTech) Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (Unesp)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cosmetic Dermatology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadipogenesis-
Palavras-chave: dc.subjectfacial rejuvenation-
Palavras-chave: dc.subjectPPAR-γ-
Palavras-chave: dc.subjectthyme-
Palavras-chave: dc.subjectwrinkles-
Título: dc.titleA new phytocosmetic preparation from Thymus vulgaris stimulates adipogenesis and controls skin aging process: In vitro studies and topical effects in a double-blind placebo-controlled clinical trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.