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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Chemyunion Química Ltda | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Caverzan, Jeanifer | - |
Autor(es): dc.creator | Mussi, Lilian | - |
Autor(es): dc.creator | Sufi, Bianca | - |
Autor(es): dc.creator | Padovani, Giovana | - |
Autor(es): dc.creator | Nazato, Lucas | - |
Autor(es): dc.creator | Camargo, Flavio B. | - |
Autor(es): dc.creator | Magalhães, Wagner V. | - |
Autor(es): dc.creator | Di Stasi, Luiz C. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:44:35Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:44:35Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1111/jocd.13818 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/205531 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/205531 | - |
Descrição: dc.description | Background: The use of the injectable products for soft tissue augmentation and treatment of skin aging is an uncomfortable, invasive and related to several complications, and chronic reactions, mainly after long-term application. Efforts to develop new topically active anti-aging products with fewer adverse effects are a huge challenge that should be faced. Aims: We evaluated the anti-aging effects of a phytocosmetic preparation containing Thymus vulgaris associated with lecithin (ThymLec) on the facial wrinkles, expression lines, and face oval remodeling using a double-blind placebo-controlled clinical trial and in vitro cell culture assays. Methods: A clinical trial was conducted to evaluate the effects of ThymLec 2% on the area, length, and depth of the perioral and crow's feet wrinkles, nasolabial and smile lines, as well as face oval remodeling in female volunteers using a sophisticated Bio3D Structured-light Scanner. In the in vitro studies using 3T3-L1 mouse embryonic fibroblasts, adiponectin was measured by immunoenzymatic assay, adipogenesis by the AdipoRed reagent method, and the PPAR-γ expression by RT-PCR analysis. Results: Topical treatment with ThymLec 2% reduced facial wrinkles and expression lines promoting a face oval remodeling. In the in vitro studies, ThymLec upregulated the PPAR-γ expression increasing adiponectin production and stimulating the adipogenesis process. Conclusions: The phytocosmetic preparation containing Thymus vulgaris and lecithin is an innovative and safe topical anti-aging product promoting fat tissue augmentation by adipogenesis stimulation via the upregulation of PPAR-γ expression and adiponectin production. | - |
Descrição: dc.description | Research and Development Department Chemyunion Química Ltda | - |
Descrição: dc.description | Laboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTech) Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (Unesp) | - |
Descrição: dc.description | Laboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTech) Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (Unesp) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of Cosmetic Dermatology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | adipogenesis | - |
Palavras-chave: dc.subject | facial rejuvenation | - |
Palavras-chave: dc.subject | PPAR-γ | - |
Palavras-chave: dc.subject | thyme | - |
Palavras-chave: dc.subject | wrinkles | - |
Título: dc.title | A new phytocosmetic preparation from Thymus vulgaris stimulates adipogenesis and controls skin aging process: In vitro studies and topical effects in a double-blind placebo-controlled clinical trial | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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