Liquid biopsy based on small extracellular vesicles predicts chemotherapy response of canine multicentric lymphomas

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorAnhembi Morumbi University-
Autor(es): dc.contributorThe University of Edinburgh-
Autor(es): dc.creatorGarnica, Taismara K.-
Autor(es): dc.creatorLesbon, Jéssika C. C.-
Autor(es): dc.creatorÁvila, Ana C. F. C. M.-
Autor(es): dc.creatorRochetti, Arina L.-
Autor(es): dc.creatorMatiz, Oscar R. S. [UNESP]-
Autor(es): dc.creatorRibeiro, Roana C. S. [UNESP]-
Autor(es): dc.creatorZoppa, Aline-
Autor(es): dc.creatorNishiya, Adriana T.-
Autor(es): dc.creatorCosta, Mirela T. [UNESP]-
Autor(es): dc.creatorde Nardi, Andrigo B. [UNESP]-
Autor(es): dc.creatorArgyle, David J.-
Autor(es): dc.creatorStrefezzi, Ricardo F.-
Autor(es): dc.creatorSilveira, Juliano C.-
Autor(es): dc.creatorFukumasu, Heidge-
Data de aceite: dc.date.accessioned2022-02-22T00:44:31Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:31Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-020-77366-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205503-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205503-
Descrição: dc.descriptionLymphoma is the most common type of canine hematological malignancy where the multicentric (cMCL) form accounts for 75% of all cases. The standard treatment is the CHOP chemotherapy protocols that include cyclophosphamide, doxorubicin, vincristine and prednisone, where the majority of dogs achieve complete/partial response; however, it is very important to predict non-responsive cases to improve treatment and to develop new targeted therapies. Here we evaluate a liquid biopsy approach based on serum Small Extracellular Vesicles enriched for exosomes (SEVs) to predict cMCL chemotherapy response. Nineteen dogs at the end of the 19-week chemotherapy protocol (8 Complete Response and 11 Progressive Disease) were evaluated for serum SEVs size, concentration and screened for 95 oncomirs. PD patients had higher SEVs concentration at the diagnosis than CR patients (P = 0.034). The ROC curve was significant for SEVs concentration to predict the response to CHOP (AUC = 0.8011, P = 0.0287). A potential molecular signature based on oncomirs from SEVs (caf-miR-205, caf-miR-222, caf-mir-20a and caf-miR-93) is proposed. To the best of our knowledge, this is the first study demonstrating the potential of a liquid biopsy based on SEVs and their miRNAs content to predict the outcome of chemotherapy for canine multicentric lymphomas.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Comparative and Translational Oncology (LOCT) Department of Veterinary Medicine Faculty of Animal Science and Food Engineering University of Sao Paulo-
Descrição: dc.descriptionLaboratory of Molecular Morphophysiology and Development (LMMD) Department of Veterinary Medicine Faculty of Animal Science and Food Engineering University of Sao Paulo-
Descrição: dc.descriptionClinical Veterinary Department College of Agricultural and Veterinary Sciences São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)-
Descrição: dc.descriptionVeterinary Hospital Anhembi Morumbi Anhembi Morumbi University-
Descrição: dc.descriptionThe Roslin Institute and Royal (Dick) School of Veterinary Studies The University of Edinburgh-
Descrição: dc.descriptionClinical Veterinary Department College of Agricultural and Veterinary Sciences São Paulo State University ‘Júlio de Mesquita Filho’ (UNESP)-
Descrição: dc.descriptionFAPESP: 14/22887-0-
Descrição: dc.descriptionFAPESP: 15/21829-9-
Descrição: dc.descriptionFAPESP: 2014/02493-7-
Descrição: dc.descriptionFAPESP: 2017/15406-3-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleLiquid biopsy based on small extracellular vesicles predicts chemotherapy response of canine multicentric lymphomas-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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