Meningitis caused by streptococcus agalactiae in nile tilapia (Oreochromis niloticus): Infection and inflammatory response

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Autor(es): dc.contributorFederal University of Roraima (UFRR)-
Autor(es): dc.contributorButantan Institute-
Autor(es): dc.contributorFederal University of Rondônia (UNIR)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Brazil-
Autor(es): dc.creatorEto, Silas Fernandes-
Autor(es): dc.creatorFernandes, Dayanne Carla-
Autor(es): dc.creatorde Moraes, Alessandra Cristina-
Autor(es): dc.creatorAlecrim, João Victor da Costa-
Autor(es): dc.creatorde Souza, Pedro Galdino-
Autor(es): dc.creatorde Carvalho, Fabíola Christian Almeida-
Autor(es): dc.creatorCharlie-Silva, Ives-
Autor(es): dc.creatorBelo, Marco Antonio de Andrade [UNESP]-
Autor(es): dc.creatorPizauro, João Martins [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:44:30Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:30Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ani10112166-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205498-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205498-
Descrição: dc.descriptionStreptococcus agalactiae (Sta) of Lancefield group B is the primary etiological agent of bacterial meningitis in Nile tilapia and newborn humans. Thus, the study of this disease is of fundamental importance for aquaculture and human medicine. Additionally, elucidation of the mechanisms involved in the host–pathogenic response is important for the success of new therapies. In the present study, we elucidated important aspects of the innate immune response in the brain tissue of Nile tilapia (Oreochromis niloticus) infected by Sta. The neuroinflammatory process in the meninges started with the migration of MHC class II and CD68 + cells, production of TNF-alpha, and the effective immune response to Sta was mediated by the increased iNOs+. In conclusion, the present study brings a partial understanding of the pathophysiological and neuroinflammatory mechanisms in meningitis in Sta infected tilapia, enabling important advances in the therapy of this disease as well as the possibility of using this biological model to understand human meningitis.-
Descrição: dc.descriptionDepartment of Postgraduatein Health Sciences-PROCISA Federal University of Roraima (UFRR)-
Descrição: dc.descriptionImmunochemistry Laboratory Butantan Institute-
Descrição: dc.descriptionDepartment of Veterinary Medicine Federal University of Rondônia (UNIR)-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biomedical Sciences University of São Paulo ICB-USP-
Descrição: dc.descriptionDepartment of Preventive Veterinary Medicine of Unesp School of Agrarian and Veterinary Sciences Sao Paulo State University (Unesp)-
Descrição: dc.descriptionLaboratory of Animal Pharmacology and Toxicology University of Brazil-
Descrição: dc.descriptionDepartment of Technology School of Agrarian and Veterinary Sciences Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Preventive Veterinary Medicine of Unesp School of Agrarian and Veterinary Sciences Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Technology School of Agrarian and Veterinary Sciences Sao Paulo State University (Unesp)-
Formato: dc.format1-9-
Idioma: dc.languageen-
Relação: dc.relationAnimals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectMicroglia-
Palavras-chave: dc.subjectNeuropathy-
Palavras-chave: dc.subjectStreptococcosis-
Palavras-chave: dc.subjectTeleost fish-
Título: dc.titleMeningitis caused by streptococcus agalactiae in nile tilapia (Oreochromis niloticus): Infection and inflammatory response-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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