Virulence Factors and Antifungal Susceptibility in Candida Species Isolated from Dermatomycosis Patients

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorLauro de Souza Lima Institute-
Autor(es): dc.contributorAdolfo Lutz Institute-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMello, Victor Galvão-
Autor(es): dc.creatorEscudeiro, Heloisa-
Autor(es): dc.creatorWeckwerth, Ana Carolina Villas Bôas-
Autor(es): dc.creatorAndrade, Maria Izilda-
Autor(es): dc.creatorFusaro, Ana Elisa-
Autor(es): dc.creatorde Moraes, Eloise Brasil [UNESP]-
Autor(es): dc.creatorRuiz, Luciana da Silva [UNESP]-
Autor(es): dc.creatorBaptista, Ida Maria Foschiani Dias [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:44:30Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:30Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11046-020-00509-x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205494-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205494-
Descrição: dc.descriptionDermatomycoses caused by Candida spp. are increasingly common, however there are few reports in the literature regarding their epidemiology, pathogenesis and antifungal susceptibility of these fungal pathogens. This study aimed to identify, characterize virulence and determine the antifungal susceptibility of Candida species isolated from patients with dermatomycoses. We studied a total of 45 yeast samples isolated from dermal scrapings from patients treated at a public hospital, Bauru, São Paulo, Brazil. After identification, the samples were analyzed for protease activity, phospholipase, biofilm formation and antifungal susceptibility. The most common species was Candida albicans (40%), followed by C. krusei (22.22%), C. parapsilosis complex (22.22%) and C. famata (6.67%). Regarding virulence mechanisms, 57.78% and 28.89% of the samples showed enzymatic activity for protease and phospholipase, respectively. A total of 13.33% of the samples showed secretion of both enzymes. All isolates were biofilm producers, and a higher production was observed in C. tropicalis isolates. Regarding the antifungal susceptibility test, 97.78% of the samples had the highest levels of the minimal inhibitory concentration (MIC) for terbinafine, and one C. krusei sample showed intermediate susceptibility to fluconazole. The correct identification of dermatomycosis-related microorganisms, as well as a better knowledge of their pathogenicity and susceptibility against the antifungals used in the clinic, is extremely important for an efficient preventive and therapeutic action.-
Descrição: dc.descriptionLauro de Souza Lima Institute-
Descrição: dc.descriptionAdolfo Lutz Institute-
Descrição: dc.descriptionMedical School São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionMedical School São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP)-
Formato: dc.format71-80-
Idioma: dc.languageen-
Relação: dc.relationMycopathologia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifungals-
Palavras-chave: dc.subjectCandida spp-
Palavras-chave: dc.subjectDermatomycoses-
Palavras-chave: dc.subjectEpidemiology-
Palavras-chave: dc.subjectPathogenesis-
Palavras-chave: dc.subjectVirulence-
Título: dc.titleVirulence Factors and Antifungal Susceptibility in Candida Species Isolated from Dermatomycosis Patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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