Effects of rocuronium, sugammadex and rocuronium‐sugammadex complex on coagulation in rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal Fluminense (UFF)-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorMartini Hospital Groningen-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorLima Cavalcanti, Ismar-
Autor(es): dc.creatorBraga, Estêvão Luiz Carvalho-
Autor(es): dc.creatorVerçosa, Nubia-
Autor(es): dc.creatorSchanaider, Alberto-
Autor(es): dc.creatorBarrucand, Louis-
Autor(es): dc.creatorBoer, Hans Donald de-
Autor(es): dc.creatorVane, Luiz [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:44:29Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:29Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bjan.2020.08.007-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205492-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205492-
Descrição: dc.descriptionBackground and objectives: Sugammadex is an alternative pharmacological drug capable of reversing neuromuscular blockades without the limitations that are presented by anticholinesterase drugs. Coagulation disorders that are related to treatment with sugammadex were reported. The exact mechanism of the effects on coagulation are not fully understood. The objective of this research is to evaluate the effects of rocuronium, sugammadex and the rocuronium‐sugammadex complex on coagulation in an experimental model in rats. Methods: This is an experimental randomized animal study. Wistar rats were randomly assigned into the following groups: the Control Group; the Ssal Group – 0.5 mL of intravenous saline; the Sugammadex Group – intravenous sugammadex (100 mg.kg‐1); and the Rocuronium‐Sugammadex Group – intravenous solution with rocuronium (3.75 mg.kg‐1) and sugammadex (100 mg.kg‐1). Anesthesia was performed by using isoflurane with controlled ventilation. Coagulation factors were measured 10 minutes after the end of the preoperative preparation and 30 minutes after the administration of the drugs in accordance with the chosen groups. Results: Platelet counts, prothrombin times and activated partial thromboplastin times were similar between the groups and between the moments within each group. There were reductions in the plasma fibrinogen levels between sample times 1 and 2 in the Rocuronium‐Sugammadex group (p = 0.035). Conclusions: The rocuronium‐sugammadex complex promoted reductions in plasma fibrinogen counts, although the levels were still within normal limits.-
Descrição: dc.descriptionUniversidade Federal Fluminense-
Descrição: dc.descriptionUniversidade Federal do Rio de Janeiro-
Descrição: dc.descriptionMartini Hospital Groningen-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP)-
Formato: dc.format635-641-
Idioma: dc.languageen-
Idioma: dc.languagept_BR-
Relação: dc.relationBrazilian Journal of Anesthesiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBlood coagulation-
Palavras-chave: dc.subjectRocuronium-
Palavras-chave: dc.subjectSugammadex-
Título: dc.titleEffects of rocuronium, sugammadex and rocuronium‐sugammadex complex on coagulation in rats-
Título: dc.titleEfeitos do rocurônio, sugamadex e complexo rocurônio‐sugamadex sobre a coagulação em ratos-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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