Moderate, but not excessive, training attenuates autophagy machinery in metabolic tissues

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorTufts University-
Autor(es): dc.creatorda Rocha, Alisson L.-
Autor(es): dc.creatorPinto, Ana P.-
Autor(es): dc.creatorMorais, Gustavo P.-
Autor(es): dc.creatorMarafon, Bruno B.-
Autor(es): dc.creatorRovina, Rafael L.-
Autor(es): dc.creatorVeras, Allice S. C. [UNESP]-
Autor(es): dc.creatorTeixeira, Giovana R. [UNESP]-
Autor(es): dc.creatorPauli, José R.-
Autor(es): dc.creatorde Moura, Leandro P.-
Autor(es): dc.creatorCintra, Dennys E.-
Autor(es): dc.creatorRopelle, Eduardo R.-
Autor(es): dc.creatorRivas, Donato A.-
Autor(es): dc.creatorda Silva, Adelino S. R.-
Data de aceite: dc.date.accessioned2022-02-22T00:44:24Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:24Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms21228416-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205470-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205470-
Descrição: dc.descriptionThe protective effects of chronic moderate exercise-mediated autophagy include the prevention and treatment of several diseases and the extension of lifespan. In addition, physical exercise may impair cellular structures, requiring the action of the autophagy mechanism for clearance and renovation of damaged cellular components. For the first time, we investigated the adaptations on basal autophagy flux in vivo in mice’s liver, heart, and skeletal muscle tissues submitted to four different chronic exercise models: endurance, resistance, concurrent, and overtraining. Measuring the autophagy flux in vivo is crucial to access the functionality of the autophagy pathway since changes in this pathway can occur in more than five steps. Moreover, the responses of metabolic, performance, and functional parameters, as well as genes and proteins related to the autophagy pathway, were addressed. In summary, the regular exercise models exhibited normal/enhanced adaptations with reduced autophagy-related proteins in all tissues. On the other hand, the overtrained group presented higher expression of Sqstm1 and Bnip3 with negative morphological and physical performance adaptations for the liver and heart, respectively. The groups showed different adaptions in autophagy flux in skeletal muscle, suggesting the activation or inhibition of basal autophagy may not always be related to improvement or impairment of performance.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionRibeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP)-
Descrição: dc.descriptionSão Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education State University of São Paulo (UNESP)-
Descrição: dc.descriptionLaboratory of Molecular Biology of Exercise (LaBMEx) School of Applied Sciences University of Campinas (UNICAMP)-
Descrição: dc.descriptionNutrition Exercise Physiology and Sarcopenia Laboratory United States Tufts University-
Descrição: dc.descriptionSão Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education State University of São Paulo (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2017/09038-1-
Descrição: dc.descriptionFAPESP: 2017/12765-2-
Descrição: dc.descriptionFAPESP: 2017/17646-1-
Descrição: dc.descriptionFAPESP: 2017/19869-8-
Descrição: dc.descriptionFAPESP: 2019/00855-2-
Descrição: dc.descriptionCNPq: 301279/2019-5-
Formato: dc.format1-21-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutophagy-
Palavras-chave: dc.subjectColchicine-
Palavras-chave: dc.subjectConcurrent training-
Palavras-chave: dc.subjectEndurance training-
Palavras-chave: dc.subjectExercise-
Palavras-chave: dc.subjectOvertraining-
Palavras-chave: dc.subjectResistance training-
Título: dc.titleModerate, but not excessive, training attenuates autophagy machinery in metabolic tissues-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.