HLA-DPB1 and HLA-C alleles are associated with leprosy in a Brazilian population

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Autor(es): dc.contributorLauro de Souza Lima Institute-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorPontifícia Universidade Católica do Paraná-
Autor(es): dc.contributorOswaldo Cruz Institute-Fiocruz-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.creatorCovolo de Souza-Santana, Fabiana-
Autor(es): dc.creatorQuerino, Gislaine Aparecida [UNESP]-
Autor(es): dc.creatorMendes Camargo, Rodrigo [UNESP]-
Autor(es): dc.creatorNieto Brito de Souza, Vânia [UNESP]-
Autor(es): dc.creatorBettoni Ballallai Mangilli, Priscila-
Autor(es): dc.creatorTávora Mira, Marcelo-
Autor(es): dc.creatorCavalcanti Bezerra, Ohanna-
Autor(es): dc.creatorKehdy, Fernanda-
Autor(es): dc.creatorLaguila Visentainer, Jeane Eliete-
Autor(es): dc.creatorAlves, Hugo Vicentin-
Autor(es): dc.creatorJarduli, Luciana Ribeiro-
Autor(es): dc.creatorOzório Moraes, Milton-
Autor(es): dc.creatorValin Camarinha Marcos, Elaine-
Autor(es): dc.creatorPereira Latini, Ana Carla [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:44:23Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:23Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.humimm.2020.10.008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205463-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205463-
Descrição: dc.descriptionDespite intense efforts, the number of new cases of leprosy has remained significantly high over the past 20 years. Host genetic background is strongly linked to the pathogenesis of this disease, which is caused by Mycobacterium leprae (M. leprae), and there is a consensus that the most significant genetic association with leprosy is attributed to the major histocompatibility complex (MHC). Here, we investigated the association of human leukocyte antigen (HLA) class I and II genes with leprosy in a Brazilian population encompassing 826 individuals from a hyperendemic area of Brazil; HLA typing of class I (-A, -B, -C) and class II (-DRB1, -DQA1, -DQB1, -DPA1, and -DPB1) loci was conducted. Initially, the associations were tested using the chi-square test, with p-values adjusted using the false discovery rate (FDR) method. Next, statistically significant signals of the associations were submitted to logistic regression analyses to adjust for sex and molecular ancestry data. The results showed that HLA-C*08, -DPB1*04, and -DPB1*18 were associated with protective effects, while HLA-C*12 and -DPB1*105 were associated with susceptibility to leprosy. Thus, our findings reveal new associations between leprosy and the HLA-DPB1 locus and confirm previous associations between the HLA-C locus and leprosy.-
Descrição: dc.descriptionLauro de Souza Lima Institute-
Descrição: dc.descriptionSão Paulo State University (UNESP) Medical School-
Descrição: dc.descriptionGraduate Program in Health Sciences School of Medicine Pontifícia Universidade Católica do Paraná-
Descrição: dc.descriptionLeprosy Laboratory Oswaldo Cruz Institute-Fiocruz-
Descrição: dc.descriptionLaboratory of Immunogenetics Department of Basic Health Sciences Maringá State University (UEM)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Medical School-
Formato: dc.format11-18-
Idioma: dc.languageen-
Relação: dc.relationHuman Immunology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGenetic susceptibility-
Palavras-chave: dc.subjectHLA-
Palavras-chave: dc.subjectLeprosy-
Palavras-chave: dc.subjectMycobacterium leprae-
Título: dc.titleHLA-DPB1 and HLA-C alleles are associated with leprosy in a Brazilian population-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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