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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Rice University | - |
Autor(es): dc.contributor | Brazilian Center for Research in Energy and Materials-CNPEM | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | University of Houston | - |
Autor(es): dc.contributor | University of Costa Rica | - |
Autor(es): dc.contributor | Military Institute of Engineering | - |
Autor(es): dc.contributor | Baylor College of Medicine | - |
Autor(es): dc.contributor | Northeastern University | - |
Autor(es): dc.creator | Contessoto, Vinícius G. [UNESP] | - |
Autor(es): dc.creator | Cheng, Ryan R. | - |
Autor(es): dc.creator | Hajitaheri, Arya | - |
Autor(es): dc.creator | Dodero-Rojas, Esteban | - |
Autor(es): dc.creator | Mello, Matheus F. | - |
Autor(es): dc.creator | Lieberman-Aiden, Erez | - |
Autor(es): dc.creator | Wolynes, Peter G. | - |
Autor(es): dc.creator | Di Pierro, Michele | - |
Autor(es): dc.creator | Onuchic, José N. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:44:20Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:44:20Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-01-07 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1093/nar/gkaa818 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/205441 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/205441 | - |
Descrição: dc.description | We introduce the Nucleome Data Bank (NDB), a web-based platform to simulate and analyze the three-dimensional (3D) organization of genomes. The NDB enables physics-based simulation of chromosomal structural dynamics through the MEGABASE + MiChroM computational pipeline. The input of the pipeline consists of epigenetic information sourced from the Encode database; the output consists of the trajectories of chromosomal motions that accurately predict Hi-C and fluorescence insitu hybridization data, as well as multiple observations of chromosomal dynamics in vivo. As an intermediate step, users can also generate chromosomal sub-compartment annotations directly from the same epigenetic input, without the use of any DNA-DNA proximity ligation data. Additionally, the NDB freely hosts both experimental and computational structural genomics data. Besides being able to perform their own genome simulations and download the hosted data, users can also analyze and visualize the same data through custom-designed web-based tools. In particular, the one-dimensional genetic and epigenetic data can be overlaid onto accurate 3D structures of chromosomes, to study the spatial distribution of genetic and epigenetic features. The NDB aims to be a shared resource to biologists, biophysicists and all genome scientists. The NDB is available at https://ndb.rice.edu. | - |
Descrição: dc.description | Welch Foundation | - |
Descrição: dc.description | National Science Foundation | - |
Descrição: dc.description | Center for Theoretical Biological Physics Rice University | - |
Descrição: dc.description | Brazilian Biorenewables National Laboratory-LNBR Brazilian Center for Research in Energy and Materials-CNPEM | - |
Descrição: dc.description | Department of Physics São Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences | - |
Descrição: dc.description | Department of Computer Science University of Houston | - |
Descrição: dc.description | Theoretical and Computational Physics Laboratory University of Costa Rica | - |
Descrição: dc.description | Chemical Engineering Department Military Institute of Engineering | - |
Descrição: dc.description | The Center for Genome Architecture Department of Molecular and Human Genetics Baylor College of Medicine | - |
Descrição: dc.description | Department of Physics and Astronomy Rice University | - |
Descrição: dc.description | Department of Chemistry Rice University | - |
Descrição: dc.description | Department of Biosciences Rice University | - |
Descrição: dc.description | Department of Physics Northeastern University | - |
Descrição: dc.description | Department of Physics São Paulo State University (UNESP) Institute of Biosciences Humanities and Exact Sciences | - |
Descrição: dc.description | Welch Foundation: C-0016 | - |
Descrição: dc.description | Welch Foundation: C-1792 | - |
Descrição: dc.description | National Science Foundation: CHE-1614101 | - |
Descrição: dc.description | National Science Foundation: PHY-2019745 | - |
Formato: dc.format | D172-D182 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Nucleic Acids Research | - |
???dc.source???: dc.source | Scopus | - |
Título: dc.title | The Nucleome Data Bank: Web-based resources to simulate and analyze the three-dimensional genome | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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