Improvement of carotenoids production from Rhodotorula glutinis CCT-2186

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Aveiro-
Autor(es): dc.contributorThe University of Manchester-
Autor(es): dc.contributorPólo II – Pinhal de Marrocos-
Autor(es): dc.creatorMussagy, Cassamo Ussemane [UNESP]-
Autor(es): dc.creatorGuimarães, Ana Alice Carizia [UNESP]-
Autor(es): dc.creatorRocha, Lara Vicente Ferreira [UNESP]-
Autor(es): dc.creatorWinterburn, James-
Autor(es): dc.creatorSantos-Ebinuma, Valéria de Carvalho [UNESP]-
Autor(es): dc.creatorPereira, Jorge Fernando Brandão [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:44:12Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:12Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-01-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bej.2020.107827-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205386-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205386-
Descrição: dc.descriptionRhodotorula strains can produce industrial valuable bioproducts. In this work, the production of carotenoids, and lipids by Rhodotorula glutinis using different nitrogen sources was evaluated. Two statistical experimental designs were applied to improve carotenoid production: a first 25−1 fractional factorial design evaluating the influence of independent variables pH, nitrogen source, glucose, KH2PO4 and MgSO4 concentration; a second 22 central factorial design to optimize the effect of pH and nitrogen sources. After the optimization using two statistical designs, a culture mediium composed of (in g/L) glucose (10), asparagine (10), NH4NO3 (4), KH2PO4 (0.52), MgSO4 (0.52) was found as the best for the production of carotenoids at a pH 5 and 30 °C. The best bioprocess was scaled-up to a 5 L stirred-tank bioreactor. The change to a bioreactor allowed to improve aeration and agitation conditions, and consequently, increasing the production yields (m/v) in, approximately, 25.83 %, 11.88 %, 24.50 % and 10.32 % for β-carotene, torularhodin, torulene and lipids, respectively. The combined supplementation of the culture media with both organic (asparagine) and inorganic nitrogen (ammonium nitrate) sources was primordial for enhancing the carotenogenesis. R. glutinis are very efficient in the production of valuable carotenoids and lipids, presenting high potential of yeast for the industrial production of more sustainable cosmetic, pharmaceutical, and food products.-
Descrição: dc.descriptionDepartment of Engineering Bioprocesses and Biotechnology School of Pharmaceutical Sciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionCICECO-Aveiro Institute of Materials Department of Chemistry University of Aveiro-
Descrição: dc.descriptionDepartment of Chemical Engineering and Analytical Science The University of Manchester-
Descrição: dc.descriptionUniv Coimbra CIEPQPF Department of Chemical Engineering Rua Sílvio Lima Pólo II – Pinhal de Marrocos-
Descrição: dc.descriptionDepartment of Engineering Bioprocesses and Biotechnology School of Pharmaceutical Sciences Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationBiochemical Engineering Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectLipids-
Palavras-chave: dc.subjectProduction-
Palavras-chave: dc.subjectRhodotorula glutinis-
Palavras-chave: dc.subjectTorularhodin-
Palavras-chave: dc.subjectTorulene-
Palavras-chave: dc.subjectYeast-
Palavras-chave: dc.subjectβ-carotene-
Título: dc.titleImprovement of carotenoids production from Rhodotorula glutinis CCT-2186-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.