Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Houston Methodist Hospital | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | NYU Shanghai | - |
Autor(es): dc.contributor | NYU-ECNU Institute of Cognitive Neuroscience at NYU Shanghai | - |
Autor(es): dc.contributor | New York University | - |
Autor(es): dc.creator | Wolfe, Tatiana | - |
Autor(es): dc.creator | Hoffman, Kristopher | - |
Autor(es): dc.creator | Hogan, Matthew K. | - |
Autor(es): dc.creator | Salazar, Betsy | - |
Autor(es): dc.creator | Tang, Xiufeng | - |
Autor(es): dc.creator | Chaboub, Lesley | - |
Autor(es): dc.creator | Quini, Caio C. [UNESP] | - |
Autor(es): dc.creator | Lu, Zhong-Lin | - |
Autor(es): dc.creator | Horner, Philip J. | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:44:06Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:44:06Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-04-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1002/jmri.27397 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/205354 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/205354 | - |
Descrição: dc.description | Background: Neurodegeneration is a complex cellular process linked to prompt changes in myelin integrity and gradual neuron loss. Current imaging techniques offer estimations of myelin volumes in lesions/remyelinated areas but are limited to detect subtle injury. Purpose: To investigate whether measurements detected by a signal hierarchically isolated as a function of time-to-echo (SHIFT) MRI technique can determine changes in myelin integrity and fiber axolemma. Study Type: Prospective animal model. Animal Model: Surgically demyelinated spinal cord (SC) injury model in rodents (n = 6). Field Strength/Sequence: Gradient-echo spin-echo at 3T. Assessment: Multicompartment T2 relaxations were computed by SHIFT MRI in 75-microns-resolution images of the SC injury penumbra region 2 weeks post-trauma. G-ratio and axolemma delamination were assessed by transmission electron microscopy (TEM) in intact and injured samples. SC myelinated nerve fraction was computed by SHIFT MRI prospectively and assessed histologically. Statistical Tests: Relations between SHIFT-isolated T2-components and TEM measurements were studied using linear regression and t-tests. Pearson's correlation and significance were computed to determine the SHIFT's sensitivity to detect myelinated fibers ratio in gray matter. Regularized least-squares-based ranking analysis was employed to determine SHIFT MRI's ability to discern intact and injured myelinated nerves. Results: Biexponential signals isolated by SHIFT MRI for intact vs. lesion penumbra exhibited changes in T2, shifting from intermediate components (25 ± 2 msec) to long (43 ± 11 msec) in white matter, and similarly in gray matter regions-of-interest (31 ± 2 to 46 ± 16 msec). These changes correlated highly with TEM g-ratio and axon delamination measurements (P < 0.05). Changes in short T2 components were observed but not statistically significant (8.5 ± 0.5 to 7 ± 3 msec, P = 0.445, and 4.0 ± 0.9 to 7 ± 3 msec, P = 0.075, respectively). SHIFT MRI's ability to detect myelinated fibers within gray matter was confirmed (P < 0.001). Data Conclusion: Changes detected by SHIFT MRI are associated with abnormal intermembrane spaces formed upon mild injury, directly correlated with early neuro integrity loss. Level of Evidence 1. Technical Efficacy Stage 2. | - |
Descrição: dc.description | Center for Neuroregneration Department of Neurosurgery Houston Methodist Research Institute Houston Methodist Hospital | - |
Descrição: dc.description | Department of Biological Physics Universidade Estadual Paulista UNESP | - |
Descrição: dc.description | Division of Arts and Sciences NYU Shanghai | - |
Descrição: dc.description | NYU-ECNU Institute of Cognitive Neuroscience at NYU Shanghai | - |
Descrição: dc.description | Center for Neural Science and Department of Psychology New York University | - |
Descrição: dc.description | Department of Biological Physics Universidade Estadual Paulista UNESP | - |
Formato: dc.format | 1162-1174 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of Magnetic Resonance Imaging | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | mild neuro injury | - |
Palavras-chave: dc.subject | neurodegeneration | - |
Palavras-chave: dc.subject | quantitative MRI | - |
Palavras-chave: dc.subject | rat spinal cord | - |
Palavras-chave: dc.subject | spinal cord injury | - |
Palavras-chave: dc.subject | T2 relaxation | - |
Título: dc.title | Quantification of Myelinated Nerve Fraction and Degeneration in Spinal Cord Neuropil by SHIFT MRI | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: