Tomato-oleoresin anti-inflammatory effect recovers obesity-induced cardiac dysfunction by modulating myocardial calcium handling

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorFerron, Artur Junio Togneri [UNESP]-
Autor(es): dc.creatorFrancisqueti-Ferron, Fabiane Valentini [UNESP]-
Autor(es): dc.creatorDe Almeida Silva, Carol Cristina Vágula [UNESP]-
Autor(es): dc.creatorBazan, Silmeia Garcia Zanati [UNESP]-
Autor(es): dc.creatorDe Campos, Dijon Henrique Salomé [UNESP]-
Autor(es): dc.creatorGarcia, Jéssica Leite [UNESP]-
Autor(es): dc.creatorGhiraldeli, Luciana [UNESP]-
Autor(es): dc.creatorMinatel, Igor Otávio [UNESP]-
Autor(es): dc.creatorCorrea, Camila Renata [UNESP]-
Autor(es): dc.creatorMoreto, Fernando [UNESP]-
Autor(es): dc.creatorFerreira, Ana Lucia Anjos [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:44:01Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:01Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.33594/000000284-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205320-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205320-
Descrição: dc.descriptionBackground/Aims: Considering the importance of inflammation on obesity-related disorders pathogenesis, including cardiac dysfunction, the interest in natural anti-inflammatory therapeutic strategies has emerged. The lycopene is a carotenoid presents in tomato and red fruits that displays anti-inflammatory properties. In this sense, we will evaluate the anti-inflammatory effect of tomato-oleoresin supplementation on obesity- related cardiac dysfunction by modulating myocardial calcium kinetic. Methods: Male Wistar rats were initially randomized into 2 experimental groups: (Control, n= 20) or high sugar- fat diet (HSF, n=20) for 20 weeks. At week 20th, once detected the cardiac dysfunction (cardiac remodeling, systolic and diastolic dysfunction) by echocardiography in HSF group, animals were randomly divided to begin the treatment with tomato-oleoresin, performing 4 groups: Control (n= 10); Control + tomato tomato-oleoresin supplementation (Control + Ly, n= 10); HSF (n= 10) or HSF + tomato tomato-oleoresin supplementation (HSF + Ly, n= 10). Tomato oleoresin was mixed with maize oil equivalent to 10mg lycopene/kg body weight (BW) per day and given orally, by gavage, every morning for a 10-week period. It was analyzed cardiac inflammatory parameters by the enzyme-linked immunosorbent assay (ELISA) and in vivo (echocardiography) and in vitro (studying isolated papillary muscles from the left ventricle) cardiac function. The groups were compared by Two-Way analysis of variance (ANOVA). Results: The HSF diet induced cardiac dysfunction (FS(%) C: 60.4±1.3; C+Ly: 60.9±1.3; HSF: 51.7±1.3; HSF+Ly: 59.4±1.4) and inflammation (TNF-a: C: 1.88±0.41; C+Ly: 1.93±1.01; HSF: 4.58±1.99; HSF+Ly: 2.03±0.55; IL-6: C: 0.58±0.16; C+Ly: 0.40±0.16; HSF: 2.00±0.45; HSF+Ly: 0.53±0.26; MCP-1: C: 0.31±0.08; C+Ly: 0.43±0.22; HSF: 1.54±0.32; HSF+Ly: 0.50±0.16). Tomato-oleoresin supplementation improved cardiac remodeling and dysfunction, cardiac inflammation and myocardial calcium kinetic. Conclusion: the anti-inflammatory effect of tomato-oleoresin supplementation treated the obesity-induced cardiac dysfunction by modulating myocardial calcium handling.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionMedical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionMedical School Sao Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2020/12578-0-
Formato: dc.format1013-1025-
Idioma: dc.languageen-
Relação: dc.relationCellular Physiology and Biochemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCalcium kinetic-
Palavras-chave: dc.subjectCardiac dysfunction-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectLycopene-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectPapillary muscle-
Título: dc.titleTomato-oleoresin anti-inflammatory effect recovers obesity-induced cardiac dysfunction by modulating myocardial calcium handling-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.