Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Ferron, Artur Junio Togneri [UNESP] | - |
Autor(es): dc.creator | Francisqueti-Ferron, Fabiane Valentini [UNESP] | - |
Autor(es): dc.creator | De Almeida Silva, Carol Cristina Vágula [UNESP] | - |
Autor(es): dc.creator | Bazan, Silmeia Garcia Zanati [UNESP] | - |
Autor(es): dc.creator | De Campos, Dijon Henrique Salomé [UNESP] | - |
Autor(es): dc.creator | Garcia, Jéssica Leite [UNESP] | - |
Autor(es): dc.creator | Ghiraldeli, Luciana [UNESP] | - |
Autor(es): dc.creator | Minatel, Igor Otávio [UNESP] | - |
Autor(es): dc.creator | Correa, Camila Renata [UNESP] | - |
Autor(es): dc.creator | Moreto, Fernando [UNESP] | - |
Autor(es): dc.creator | Ferreira, Ana Lucia Anjos [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:44:01Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:44:01Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.33594/000000284 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/205320 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/205320 | - |
Descrição: dc.description | Background/Aims: Considering the importance of inflammation on obesity-related disorders pathogenesis, including cardiac dysfunction, the interest in natural anti-inflammatory therapeutic strategies has emerged. The lycopene is a carotenoid presents in tomato and red fruits that displays anti-inflammatory properties. In this sense, we will evaluate the anti-inflammatory effect of tomato-oleoresin supplementation on obesity- related cardiac dysfunction by modulating myocardial calcium kinetic. Methods: Male Wistar rats were initially randomized into 2 experimental groups: (Control, n= 20) or high sugar- fat diet (HSF, n=20) for 20 weeks. At week 20th, once detected the cardiac dysfunction (cardiac remodeling, systolic and diastolic dysfunction) by echocardiography in HSF group, animals were randomly divided to begin the treatment with tomato-oleoresin, performing 4 groups: Control (n= 10); Control + tomato tomato-oleoresin supplementation (Control + Ly, n= 10); HSF (n= 10) or HSF + tomato tomato-oleoresin supplementation (HSF + Ly, n= 10). Tomato oleoresin was mixed with maize oil equivalent to 10mg lycopene/kg body weight (BW) per day and given orally, by gavage, every morning for a 10-week period. It was analyzed cardiac inflammatory parameters by the enzyme-linked immunosorbent assay (ELISA) and in vivo (echocardiography) and in vitro (studying isolated papillary muscles from the left ventricle) cardiac function. The groups were compared by Two-Way analysis of variance (ANOVA). Results: The HSF diet induced cardiac dysfunction (FS(%) C: 60.4±1.3; C+Ly: 60.9±1.3; HSF: 51.7±1.3; HSF+Ly: 59.4±1.4) and inflammation (TNF-a: C: 1.88±0.41; C+Ly: 1.93±1.01; HSF: 4.58±1.99; HSF+Ly: 2.03±0.55; IL-6: C: 0.58±0.16; C+Ly: 0.40±0.16; HSF: 2.00±0.45; HSF+Ly: 0.53±0.26; MCP-1: C: 0.31±0.08; C+Ly: 0.43±0.22; HSF: 1.54±0.32; HSF+Ly: 0.50±0.16). Tomato-oleoresin supplementation improved cardiac remodeling and dysfunction, cardiac inflammation and myocardial calcium kinetic. Conclusion: the anti-inflammatory effect of tomato-oleoresin supplementation treated the obesity-induced cardiac dysfunction by modulating myocardial calcium handling. | - |
Descrição: dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
Descrição: dc.description | Medical School Sao Paulo State University (UNESP) | - |
Descrição: dc.description | Institute of Biosciences Sao Paulo State University (UNESP) | - |
Descrição: dc.description | Medical School Sao Paulo State University (UNESP) | - |
Descrição: dc.description | Institute of Biosciences Sao Paulo State University (UNESP) | - |
Descrição: dc.description | FAPESP: 2020/12578-0 | - |
Formato: dc.format | 1013-1025 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Cellular Physiology and Biochemistry | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Calcium kinetic | - |
Palavras-chave: dc.subject | Cardiac dysfunction | - |
Palavras-chave: dc.subject | Inflammation | - |
Palavras-chave: dc.subject | Lycopene | - |
Palavras-chave: dc.subject | Obesity | - |
Palavras-chave: dc.subject | Papillary muscle | - |
Título: dc.title | Tomato-oleoresin anti-inflammatory effect recovers obesity-induced cardiac dysfunction by modulating myocardial calcium handling | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: