Cyclophosphamide modulated the foreign body inflammatory reaction in tilapia (Oreochromis niloticus)

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Rondonia (UNIR)-
Autor(es): dc.contributorFederal University of Roraima (UFRR)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorBrasil University-
Autor(es): dc.creatorCharlie-Silva, Ives-
Autor(es): dc.creatorConde, Gabriel [UNESP]-
Autor(es): dc.creatorMendonça Gomes, Juliana Moreira-
Autor(es): dc.creatorJohnny da Rosa Prado, Ed [UNESP]-
Autor(es): dc.creatorFernandes, Dayanne Carla [UNESP]-
Autor(es): dc.creatorCristina de Moraes, Alessandra-
Autor(es): dc.creatorEto, Silas Fernandes-
Autor(es): dc.creatorConceição, Katia-
Autor(es): dc.creatorAntonio de Andrade Belo, Marco [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:44:00Z-
Data de disponibilização: dc.date.available2022-02-22T00:44:00Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.fsi.2020.09.039-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205312-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205312-
Descrição: dc.descriptionIn order to understand events and mechanisms present in the pathophysiology of tilapia's chronic inflammation and based on the immunomodulatory activity attributed to cyclophosphamide which is widely used to suppress immune responses in human medicine, the present study investigated the effects of cyclophosphamide (CYP) treatment on the modulation of foreign body inflammatory reaction in Nile tilapia (Oreochromis niloticus) with round glass coverslip implanted in the subcutaneous tissue (9 mm of diameter). Forty tilapia (151 ± 10,2 g) were randomly distributed in 5 aquariums (n = 8) with a capacity of 250 L of water each, to compose two treatments (sampled 3 and 6 days post-implantation): implanted/untreated (control) and implanted/treated with 200 mg of CYP kg−1 of b.w., through i.p. route. A fifth group (n = 8) was sampled without any stimulus (naive) to obtain reference values. CYP-treated tilapia showed decrease in macrophage accumulation, giant cell formation and Langhans cells on the glass coverslip when compared to control fish. The treatment with CYP resulted in decrease of leukocyte and thrombocyte counts. Decrease in alpha-2-macroglobulin, ceruloplasmin, albumin and transferrin levels, as well as increase in haptoglobin, complement C3 and apolipoprotein A1 were observed in tilapias during foreign body inflammation. Blood levels of complement C3, alpha-2-macroglobulin, ceruloplasmin and transferrin were modulated by treatment with CYP. Therefore, the treatment with 200 mg of CYP kg−1 of b.w. in tilapia resulted in an anti-inflammatory effect by suppressing the dynamics between leukocytes in the bloodstream and macrophage accumulation with giant cell formation in the inflamed focus, as well as by modulating APPs during foreign body reaction.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biomedical Science University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Preventive Veterinary Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionVeterinary College Federal University of Rondonia (UNIR)-
Descrição: dc.descriptionDepartment of Graduate Program in Health Sciences Federal University of Roraima (UFRR)-
Descrição: dc.descriptionLaboratório de Bioquímica de Peptídeos UNIFESP-
Descrição: dc.descriptionLaboratory of Animal Pharmacology and Toxicology Brasil University-
Descrição: dc.descriptionDepartment of Preventive Veterinary Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2012/12256-7-
Descrição: dc.descriptionFAPESP: 2013/11675-9-
Descrição: dc.descriptionCNPq: 432830/2016-2-
Descrição: dc.descriptionCNPq: 477816/2013-4-
Formato: dc.format230-237-
Idioma: dc.languageen-
Relação: dc.relationFish and Shellfish Immunology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcute phase proteins-
Palavras-chave: dc.subjectAlkylating agents-
Palavras-chave: dc.subjectChronic inflammation-
Palavras-chave: dc.subjectCichlids-
Palavras-chave: dc.subjectGiant cells-
Palavras-chave: dc.subjectInnate immunity-
Palavras-chave: dc.subjectLanghans cells-
Palavras-chave: dc.subjectMacrophages-
Título: dc.titleCyclophosphamide modulated the foreign body inflammatory reaction in tilapia (Oreochromis niloticus)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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