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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Federal University of Rondonia (UNIR) | - |
Autor(es): dc.contributor | Federal University of Roraima (UFRR) | - |
Autor(es): dc.contributor | Universidade Federal de São Paulo (UNIFESP) | - |
Autor(es): dc.contributor | Brasil University | - |
Autor(es): dc.creator | Charlie-Silva, Ives | - |
Autor(es): dc.creator | Conde, Gabriel [UNESP] | - |
Autor(es): dc.creator | Mendonça Gomes, Juliana Moreira | - |
Autor(es): dc.creator | Johnny da Rosa Prado, Ed [UNESP] | - |
Autor(es): dc.creator | Fernandes, Dayanne Carla [UNESP] | - |
Autor(es): dc.creator | Cristina de Moraes, Alessandra | - |
Autor(es): dc.creator | Eto, Silas Fernandes | - |
Autor(es): dc.creator | Conceição, Katia | - |
Autor(es): dc.creator | Antonio de Andrade Belo, Marco [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:44:00Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:44:00Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-11-30 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.fsi.2020.09.039 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/205312 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/205312 | - |
Descrição: dc.description | In order to understand events and mechanisms present in the pathophysiology of tilapia's chronic inflammation and based on the immunomodulatory activity attributed to cyclophosphamide which is widely used to suppress immune responses in human medicine, the present study investigated the effects of cyclophosphamide (CYP) treatment on the modulation of foreign body inflammatory reaction in Nile tilapia (Oreochromis niloticus) with round glass coverslip implanted in the subcutaneous tissue (9 mm of diameter). Forty tilapia (151 ± 10,2 g) were randomly distributed in 5 aquariums (n = 8) with a capacity of 250 L of water each, to compose two treatments (sampled 3 and 6 days post-implantation): implanted/untreated (control) and implanted/treated with 200 mg of CYP kg−1 of b.w., through i.p. route. A fifth group (n = 8) was sampled without any stimulus (naive) to obtain reference values. CYP-treated tilapia showed decrease in macrophage accumulation, giant cell formation and Langhans cells on the glass coverslip when compared to control fish. The treatment with CYP resulted in decrease of leukocyte and thrombocyte counts. Decrease in alpha-2-macroglobulin, ceruloplasmin, albumin and transferrin levels, as well as increase in haptoglobin, complement C3 and apolipoprotein A1 were observed in tilapias during foreign body inflammation. Blood levels of complement C3, alpha-2-macroglobulin, ceruloplasmin and transferrin were modulated by treatment with CYP. Therefore, the treatment with 200 mg of CYP kg−1 of b.w. in tilapia resulted in an anti-inflammatory effect by suppressing the dynamics between leukocytes in the bloodstream and macrophage accumulation with giant cell formation in the inflamed focus, as well as by modulating APPs during foreign body reaction. | - |
Descrição: dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
Descrição: dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
Descrição: dc.description | Department of Pharmacology Institute of Biomedical Science University of São Paulo (USP) | - |
Descrição: dc.description | Department of Preventive Veterinary Medicine São Paulo State University (UNESP) | - |
Descrição: dc.description | Veterinary College Federal University of Rondonia (UNIR) | - |
Descrição: dc.description | Department of Graduate Program in Health Sciences Federal University of Roraima (UFRR) | - |
Descrição: dc.description | Laboratório de Bioquímica de Peptídeos UNIFESP | - |
Descrição: dc.description | Laboratory of Animal Pharmacology and Toxicology Brasil University | - |
Descrição: dc.description | Department of Preventive Veterinary Medicine São Paulo State University (UNESP) | - |
Descrição: dc.description | FAPESP: 2012/12256-7 | - |
Descrição: dc.description | FAPESP: 2013/11675-9 | - |
Descrição: dc.description | CNPq: 432830/2016-2 | - |
Descrição: dc.description | CNPq: 477816/2013-4 | - |
Formato: dc.format | 230-237 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Fish and Shellfish Immunology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Acute phase proteins | - |
Palavras-chave: dc.subject | Alkylating agents | - |
Palavras-chave: dc.subject | Chronic inflammation | - |
Palavras-chave: dc.subject | Cichlids | - |
Palavras-chave: dc.subject | Giant cells | - |
Palavras-chave: dc.subject | Innate immunity | - |
Palavras-chave: dc.subject | Langhans cells | - |
Palavras-chave: dc.subject | Macrophages | - |
Título: dc.title | Cyclophosphamide modulated the foreign body inflammatory reaction in tilapia (Oreochromis niloticus) | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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