The role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Brasil-
Autor(es): dc.contributorTechnological Institute of Aeronautics (ITA-CTA)-
Autor(es): dc.contributorFederal University of Rio Grande do Sul-
Autor(es): dc.contributorUniversity of Michigan School of Dentistry-
Autor(es): dc.contributorNational Institute of Space Research (INPE)-
Autor(es): dc.contributorFederal University of Piauí-
Autor(es): dc.creatorSato, Tabata P. [UNESP]-
Autor(es): dc.creatorRodrigues, Bruno V. M.-
Autor(es): dc.creatorMello, Daphne C. R. [UNESP]-
Autor(es): dc.creatorMünchow, Eliseu A.-
Autor(es): dc.creatorRibeiro, Juliana S.-
Autor(es): dc.creatorMachado, João Paulo B.-
Autor(es): dc.creatorVasconcellos, Luana M. R. [UNESP]-
Autor(es): dc.creatorLobo, Anderson O.-
Autor(es): dc.creatorBottino, Marco C.-
Autor(es): dc.creatorBorges, Alexandre L. S. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:43:59Z-
Data de disponibilização: dc.date.available2022-02-22T00:43:59Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-020-03633-6-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205300-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205300-
Descrição: dc.descriptionObjectives: This study aimed to evaluate the effects of nanohydroxyapatite (nHAp) particles on the morphological, chemical, physical, and biological properties of chitosan electrospun nanofibers. Materials and methods: nHAp particles with a 1.67 Ca/P ratio were synthesized via the aqueous precipitation method, incorporated into chitosan polymer solution (0.5 wt%), and electrospun into nHAp-loaded fibers (ChHa fibers). Neat chitosan fibers (nHAp-free, Ch fibers) were used as the control. The electrospun fiber mats were characterized using morphological, topographical, chemical, thermal, and a range of biological (antibacterial, antibiofilm, cell viability, and alkaline phosphatase [ALP] activity) analyses. Data were analyzed using ANOVA and Tukey’s test (α = 0.05). Results: ChHa fibers demonstrated a bead-like morphology, with thinner (331 ± 110 nm) and smoother (Ra = 2.9 ± 0.3 μm) distribution as compared to the control fibers. Despite showing similar cell viability and ALP activity to Ch fibers, the ChHa fibers demonstrated greater antibacterial potential against most tested bacteria (except for P. intermedia), and higher antibiofilm activity against P. gingivalis biofilm. Conclusions: The incorporation of nHAp particles did not jeopardize the overall morphology, topography, physical, and biological characteristics of the chitosan nanofibers. Clinical relevance: The combination of nHAp particles with chitosan can be used to engineer bioactive, electrospun composite nanofibers with potential applications in regenerative dentistry.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology (IST) São Paulo State University (UNESP), Av Engenheiro Francisco José Longo, 777, Jardim São Dimas-
Descrição: dc.descriptionLaboratory of Biomedical Nanotechnology Universidade Brasil-
Descrição: dc.descriptionPlasma and Processes Laboratory Technological Institute of Aeronautics (ITA-CTA)-
Descrição: dc.descriptionDepartment of Oral Pathology and Microbiology IST UNESP-
Descrição: dc.descriptionDepartment of Conservative Dentistry School of Dentistry Federal University of Rio Grande do Sul-
Descrição: dc.descriptionDepartment of Cariology Restorative Sciences and Endodontics University of Michigan School of Dentistry, 1011 N. University (Room 5223)-
Descrição: dc.descriptionAssociated Laboratory of Materials and Sensor (LAS) National Institute of Space Research (INPE)-
Descrição: dc.descriptionInterdisciplinary Laboratory for Advanced Materials Federal University of Piauí-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology (IST) São Paulo State University (UNESP), Av Engenheiro Francisco José Longo, 777, Jardim São Dimas-
Descrição: dc.descriptionDepartment of Oral Pathology and Microbiology IST UNESP-
Descrição: dc.descriptionFAPESP: 2011/17877-7-
Descrição: dc.descriptionFAPESP: 2011/20345-7-
Descrição: dc.descriptionCNPq: 310659/2014-0-
Descrição: dc.descriptionCNPq: 310973/2014-7-
Formato: dc.format3095-3103-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntimicrobial-
Palavras-chave: dc.subjectChitosan-
Palavras-chave: dc.subjectElectrospinning-
Palavras-chave: dc.subjectRegeneration-
Palavras-chave: dc.subjectRegenerative dentistry-
Palavras-chave: dc.subjectScaffolds-
Título: dc.titleThe role of nanohydroxyapatite on the morphological, physical, and biological properties of chitosan nanofibers-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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