In vitro and in vivo antitumoral activity of a ternary copper (II) complex

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Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorFederal Center of Technological Education of Minas Gerais-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversity Center of Patos de Minas-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorLopes, Jeyson Césary-
Autor(es): dc.creatorBotelho, Françoise Vasconcelos-
Autor(es): dc.creatorBarbosa Silva, Marcelo José-
Autor(es): dc.creatorSilva, Suélen Fernandes [UNESP]-
Autor(es): dc.creatorPolloni, Lorena-
Autor(es): dc.creatorAlves Machado, Pedro Henrique-
Autor(es): dc.creatorRodrigues de Souza, Tiago-
Autor(es): dc.creatorGoulart, Luiz Ricardo-
Autor(es): dc.creatorSilva Caldeira, Priscila Pereira-
Autor(es): dc.creatorPereira Maia, Elene Cristina-
Autor(es): dc.creatorMorelli, Sandra-
Autor(es): dc.creatorde Oliveira-Júnior, Robson J.-
Data de aceite: dc.date.accessioned2022-02-22T00:43:51Z-
Data de disponibilização: dc.date.available2022-02-22T00:43:51Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-16-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbrc.2020.09.104-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205253-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205253-
Descrição: dc.descriptionRecently, a high number of copper derivatives has been evaluated as DNA-targeting metallodrugs, due to the lower toxicity and its potential to cleave DNA. Several strategies have been testing to develop metal compounds effective against tumour cells. In this work, the ternary copper (doxycycline)-(1,10-phenanthroline) complex [Cu(dox)(phen)]2+ was especially designed as an antitumoral drug, previously showing high cytotoxicity and DNA cleavage activity. We aimed to further investigate the in vitro cytotoxic activity in both tumoral and non-tumoral cells, in vitro genotoxic potential, and in vivo antitumor activity using BALB/C mouse injected with sarcoma S180 and Ehrlich cell lines. Our results indicated that this compound exhibits a moderate genotoxic potential, with selective growth inhibition of tumor cells, especially the murine melanoma B16F10. Its main mechanism of action seems to be through ROS generation. We have further shown a significant reduction of the implanted tumor size in the animal model, suggesting that this compound has great antitumoral potential against many tumor types. [Cu(dox)(phen)]2+ is selectively cytotoxic for melanoma B16F10 and showed high chemotherapeutic potential in vivo against implanted sarcoma S180 and Ehrlich ascites tumours.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionInstitute of Genetics and Biochemistry Federal University of Uberlândia-
Descrição: dc.descriptionInstitute of Biomedical Sciences Federal University of Uberlândia-
Descrição: dc.descriptionDepartment of Chemistry Federal Center of Technological Education of Minas Gerais-
Descrição: dc.descriptionDepartment of Chemistry Federal University of Minas Gerais-
Descrição: dc.descriptionLaboratory of Cytogenetics and Mutagenesis University Center of Patos de Minas-
Descrição: dc.descriptionChemistry Institute São Paulo State University - UNESP-
Descrição: dc.descriptionChemistry Institute São Paulo State University - UNESP-
Formato: dc.format1021-1026-
Idioma: dc.languageen-
Relação: dc.relationBiochemical and Biophysical Research Communications-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntitumoral activity-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectGenotoxicity-
Palavras-chave: dc.subjectMelanoma-
Palavras-chave: dc.subjectSarcoma-
Palavras-chave: dc.subjectTernary copper (II) complex-
Título: dc.titleIn vitro and in vivo antitumoral activity of a ternary copper (II) complex-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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