Clinical influence of calcium hydroxide and N-acetylcysteine on the levels of resolvins E1 and D2 in apical periodontitis

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversity of Maryland-
Autor(es): dc.creatorCorazza, B. J.M. [UNESP]-
Autor(es): dc.creatorMartinho, F. C.-
Autor(es): dc.creatorKhoury, R. D. [UNESP]-
Autor(es): dc.creatorToia, C. C. [UNESP]-
Autor(es): dc.creatorOrozco, E. I.F. [UNESP]-
Autor(es): dc.creatorPrado, R. F. [UNESP]-
Autor(es): dc.creatorMachado, F. P. [UNESP]-
Autor(es): dc.creatorValera, M. C. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:43:50Z-
Data de disponibilização: dc.date.available2022-02-22T00:43:50Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/iej.13403-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205252-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205252-
Descrição: dc.descriptionAim: To investigate the presence of resolvins E1 (RvE1) and D2 (RvD2) in teeth with primary endodontic infections and apical periodontitis, and to assess the influence of calcium hydroxide medication [Ca(OH)2], in association with 2% chlorhexidine gel (2% CHX gel), and N-acetylcysteine (NAC) on the levels of RvE1 and RvD2 in periapical tissues. Methodology: Thirty-six single-rooted teeth with primary endodontic infections and apical periodontitis were selected and randomly divided into three groups according to the medication: [Ca(OH)2] + saline solution (SSL) [Ca(OH)2 + SSL group] (n = 12), Ca(OH)2 + 2% chlorhexidine gel [Ca(OH)2 + 2% CHX gel group] (n = 12) and NAC [NAC group] (n = 12). Samples were collected from the periapical interstitial fluid at two different sampling times: before (S1) and after 14 days of intracanal medications (S2). Resolvins were measured using the enzyme-linked immunosorbent assay. Data were analysed using paired t-test, Wilcoxon test and Kruskal–Wallis test, followed by Dunn’s post hoc test; all statistical tests were performed at a significance level of 5%. Results: RvE1 and RvD2 were detected in 100% of the samples (36/36) at S1 and S2. Ca(OH)2 medication did not increase the levels of RvE1 or RvD2 (both P > 0.05); however, NAC significantly increased the levels of RvE1 and RvD2 after 14 days of treatment (P < 0.05). Conclusions: RvE1 and RvD2 were detected in periapical tissues from teeth with root canal infections. Moreover, calcium hydroxide medication did not increase the levels of resolvins in apical periodontitis. In contrast, the use of NAC intracanal medication significantly increased the levels of RvE1 and RvD2 after 14 days of treatment.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontic Division Institute of Science and Technology São Paulo State University – UNESP-
Descrição: dc.descriptionDepartment of Advanced Oral Sciences and Therapeutics School of Dentistry University of Maryland-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontic Division Institute of Science and Technology São Paulo State University – UNESP-
Descrição: dc.descriptionFAPESP: 2016/26012-3-
Descrição: dc.descriptionFAPESP: 2018/01703-9-
Formato: dc.format61-73-
Idioma: dc.languageen-
Relação: dc.relationInternational Endodontic Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcalcium hydroxide-
Palavras-chave: dc.subjectintracanal medication-
Palavras-chave: dc.subjectresolvins-
Palavras-chave: dc.subjectroot canal-
Título: dc.titleClinical influence of calcium hydroxide and N-acetylcysteine on the levels of resolvins E1 and D2 in apical periodontitis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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