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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Federal University of Technology – Paraná (UTFPR) | - |
Autor(es): dc.contributor | Instituto Federal Goiano | - |
Autor(es): dc.contributor | Federal University of Triangulo Mineiro | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Universidade Federal do ABC (UFABC) | - |
Autor(es): dc.creator | Stein, Angelica Miki [UNESP] | - |
Autor(es): dc.creator | da Silva, Thays Martins Vital [UNESP] | - |
Autor(es): dc.creator | Coelho, Flávia Gomes de Melo [UNESP] | - |
Autor(es): dc.creator | Rueda, André Veloso | - |
Autor(es): dc.creator | Camarini, Rosana | - |
Autor(es): dc.creator | Galduróz, Ruth Ferreira Santos [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:43:50Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:43:50Z | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2021-06-25 | - |
Data de envio: dc.date.issued | 2020-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.bbr.2020.112903 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/205245 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/205245 | - |
Descrição: dc.description | Objectives: Increased Insulin-like growth factor I (IGF-1) has been associated with improvement of cognitive function in response to exercise. Evidences indicate a role for IGF-1 in beta-amyloid clearance and reducing hyperphosphorylation tau in Alzheimer's disease (AD). There is a need to investigate the IGF-1 response to exercise in AD patients due to well-known potential effects of exercise on IGF-1. The aim of this study was to examine circulating IGF-1 levels in AD patients and older adults without dementia after acute exercise and to verify the associations among cardiorespiratory fitness, cognition and IGF-1 levels. Method: Seventy-four older adults (40 older adults without dementia and 34 AD patients) participated in this study. The outcomes included IGF-1 plasma levels and performance in the submaximal exercise stress test. Secondary outcomes included cognitive functions, depressive symptoms, level of physical activity, insulin-resistance, and cholesterol. All participants performed the incremental test on a treadmill and IGF-1 was collected before and after the exercise. Results: A tendency to the difference of baseline IGF-1 plasma levels between the groups was found. After the acute exercise AD patients also presented higher levels of circulating IGF-1 compared to the Older adults without dementia. Correlations among cardiorespiratory fitness and cognitive functions were found. Conclusion: The findings suggest that AD patients and older adults respond differently to acute exercise in terms of circulating IGF-1 levels. This response seems to indicate either an IGF-1 resistance or a compensatory exercise-induced to lower IGF-1 levels in AD patients. Cardiorespiratory fitness is associated with global cognition, executive function, attention and information processing speed. | - |
Descrição: dc.description | Instituto de Biociências Universidade Estadual Paulista (UNESP), Campus Rio Claro | - |
Descrição: dc.description | UTFPR Federal University of Technology – Paraná (UTFPR) | - |
Descrição: dc.description | Instituto Federal Goiano, Campus Avançado Hidrolândia | - |
Descrição: dc.description | Postgraduate Program in Physical Education Federal University of Triangulo Mineiro | - |
Descrição: dc.description | Departamento de Farmacologia Instituto de Ciências Biomédicas Universidade de São Paulo | - |
Descrição: dc.description | Center of Mathematics Computing and Cognition University Federal of ABC (UFABC) | - |
Descrição: dc.description | Instituto de Biociências Universidade Estadual Paulista (UNESP), Campus Rio Claro | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Behavioural Brain Research | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Alzheimer's disease | - |
Palavras-chave: dc.subject | Dementia | - |
Palavras-chave: dc.subject | Exercise | - |
Palavras-chave: dc.subject | Insulin-like growth factor I | - |
Título: dc.title | Acute exercise increases circulating IGF-1 in Alzheimer's disease patients, but not in older adults without dementia | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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