Acute exercise increases circulating IGF-1 in Alzheimer's disease patients, but not in older adults without dementia

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Technology – Paraná (UTFPR)-
Autor(es): dc.contributorInstituto Federal Goiano-
Autor(es): dc.contributorFederal University of Triangulo Mineiro-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal do ABC (UFABC)-
Autor(es): dc.creatorStein, Angelica Miki [UNESP]-
Autor(es): dc.creatorda Silva, Thays Martins Vital [UNESP]-
Autor(es): dc.creatorCoelho, Flávia Gomes de Melo [UNESP]-
Autor(es): dc.creatorRueda, André Veloso-
Autor(es): dc.creatorCamarini, Rosana-
Autor(es): dc.creatorGalduróz, Ruth Ferreira Santos [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:43:50Z-
Data de disponibilização: dc.date.available2022-02-22T00:43:50Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2020.112903-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205245-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205245-
Descrição: dc.descriptionObjectives: Increased Insulin-like growth factor I (IGF-1) has been associated with improvement of cognitive function in response to exercise. Evidences indicate a role for IGF-1 in beta-amyloid clearance and reducing hyperphosphorylation tau in Alzheimer's disease (AD). There is a need to investigate the IGF-1 response to exercise in AD patients due to well-known potential effects of exercise on IGF-1. The aim of this study was to examine circulating IGF-1 levels in AD patients and older adults without dementia after acute exercise and to verify the associations among cardiorespiratory fitness, cognition and IGF-1 levels. Method: Seventy-four older adults (40 older adults without dementia and 34 AD patients) participated in this study. The outcomes included IGF-1 plasma levels and performance in the submaximal exercise stress test. Secondary outcomes included cognitive functions, depressive symptoms, level of physical activity, insulin-resistance, and cholesterol. All participants performed the incremental test on a treadmill and IGF-1 was collected before and after the exercise. Results: A tendency to the difference of baseline IGF-1 plasma levels between the groups was found. After the acute exercise AD patients also presented higher levels of circulating IGF-1 compared to the Older adults without dementia. Correlations among cardiorespiratory fitness and cognitive functions were found. Conclusion: The findings suggest that AD patients and older adults respond differently to acute exercise in terms of circulating IGF-1 levels. This response seems to indicate either an IGF-1 resistance or a compensatory exercise-induced to lower IGF-1 levels in AD patients. Cardiorespiratory fitness is associated with global cognition, executive function, attention and information processing speed.-
Descrição: dc.descriptionInstituto de Biociências Universidade Estadual Paulista (UNESP), Campus Rio Claro-
Descrição: dc.descriptionUTFPR Federal University of Technology – Paraná (UTFPR)-
Descrição: dc.descriptionInstituto Federal Goiano, Campus Avançado Hidrolândia-
Descrição: dc.descriptionPostgraduate Program in Physical Education Federal University of Triangulo Mineiro-
Descrição: dc.descriptionDepartamento de Farmacologia Instituto de Ciências Biomédicas Universidade de São Paulo-
Descrição: dc.descriptionCenter of Mathematics Computing and Cognition University Federal of ABC (UFABC)-
Descrição: dc.descriptionInstituto de Biociências Universidade Estadual Paulista (UNESP), Campus Rio Claro-
Idioma: dc.languageen-
Relação: dc.relationBehavioural Brain Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlzheimer's disease-
Palavras-chave: dc.subjectDementia-
Palavras-chave: dc.subjectExercise-
Palavras-chave: dc.subjectInsulin-like growth factor I-
Título: dc.titleAcute exercise increases circulating IGF-1 in Alzheimer's disease patients, but not in older adults without dementia-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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