Effects of short-term physical training on the interleukin-15 signalling pathway and glucose tolerance in aged rats

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFaculty of Sport Sciences and Physical Education-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMinuzzi, Luciele Guerra [UNESP]-
Autor(es): dc.creatorda Conceição, Luciana Renata-
Autor(es): dc.creatorMuñoz, Vitor Rosetto-
Autor(es): dc.creatorVieira, Renan Fudoli Lins-
Autor(es): dc.creatorGaspar, Rafael Calais-
Autor(es): dc.creatorda Silva, Adelino S.R.-
Autor(es): dc.creatorCintra, Dennys Esper-
Autor(es): dc.creatorPereira de Moura, Leandro-
Autor(es): dc.creatorRopelle, Eduardo Rochete-
Autor(es): dc.creatorTeixeira, Ana Maria-
Autor(es): dc.creatorPauli, José Rodrigo-
Data de aceite: dc.date.accessioned2022-02-22T00:43:49Z-
Data de disponibilização: dc.date.available2022-02-22T00:43:49Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.cyto.2020.155306-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205239-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205239-
Descrição: dc.descriptionPurpose: Interleukin-15 (IL-15) is a myokine that has been proposed to modulate skeletal muscle and adipose tissue mass, as well as insulin sensitivity. However, the evidence suggesting a role for IL-15 in improving whole-body insulin sensitivity and decreasing adiposity comes mainly from studies using supraphysiological levels of this cytokine. This study examined the effect of a short-term exercise training protocol on the protein content of IL-15, it's signaling pathway, and glucose tolerance in aged rats. Methods: Fourteen Wistar rats were divided into Young Sedentary (Young, n = 4); Old Sedentary (Old, n = 5); Old Exercise (Old.Exe, n = 5) groups. The animals from the exercised group were submitted to a short-term physical exercise protocol for five days. At the end of physical training and after 16 h of the last exercise session, the animals were euthanized, and tissue collection was done. Results: Physical exercise decreased epididymal and mesenteric fat mass and promoted positive effects on glucose tolerance and insulin sensitivity. Muscle IL-15 protein levels were not changed following the short-term physical exercise training with no alterations in the post-exercise IL-15–JAK/STAT signaling pathway. We found a tendency to increased HIF1α and a significant increase in its regulator, PHD2, in the skeletal muscle after exercise. Conclusion: The elderly rats submitted to short-term aerobic physical training did not present skeletal muscle alteration in the protein content of the IL-15 and IL-15-JAK/STAT signaling pathway. However, short-term aerobic physical training was able to modulate the expression of HIF1α and its regulator PHD2, suggesting an essential role of these proteins in improving post-exercise glucose tolerance and insulin sensitivity in elderly rats.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLaboratory of Molecular Biology of Exercise (LaBMEx) University of Campinas (UNICAMP)-
Descrição: dc.descriptionPost-graduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School USP-
Descrição: dc.descriptionLaboratory of Nutritional Genomics (LabGeN) University of Campinas (UNICAMP)-
Descrição: dc.descriptionLaboratory of Cell Signalling Obesity and Comorbidities Research Center (OCRC) University of Campinas-
Descrição: dc.descriptionCEPECE – Center of Research in Sport Sciences. School of Applied Sciences University of Campinas (UNICAMP)-
Descrição: dc.descriptionUniversity of Coimbra Research Center for Sport and Physical Activity Faculty of Sport Sciences and Physical Education-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Post-Graduation Program in Movement Sciences Department of Physical Education São Paulo State University (UNESP)-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Post-Graduation Program in Movement Sciences Department of Physical Education São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2018/20872-6-
Descrição: dc.descriptionCNPq: 306535/2017-3-
Descrição: dc.descriptionCNPq: 442542/2014-3-
Descrição: dc.descriptionCAPES: 88882.306818/2018-01-
Descrição: dc.descriptionCAPES: CAPES-PRINT 001-
Descrição: dc.descriptionCAPES: PNPD/CAPES 001-
Idioma: dc.languageen-
Relação: dc.relationCytokine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAging-
Palavras-chave: dc.subjectHIF1α-
Palavras-chave: dc.subjectInsulin sensitivity-
Palavras-chave: dc.subjectInterleukin-15-
Palavras-chave: dc.subjectPhysical exercise-
Título: dc.titleEffects of short-term physical training on the interleukin-15 signalling pathway and glucose tolerance in aged rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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