Aging with rhythmicity. Is it possible? Physical exercise as a pacemaker

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorde Souza Teixeira, Alexandre Abilio-
Autor(es): dc.creatorLira, Fábio Santos [UNESP]-
Autor(es): dc.creatorRosa-Neto, José Cesar-
Data de aceite: dc.date.accessioned2022-02-22T00:43:44Z-
Data de disponibilização: dc.date.available2022-02-22T00:43:44Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-11-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2020.118453-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205209-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205209-
Descrição: dc.descriptionAging is associated with gradual decline in numerous physiological processes, including a reduction in metabolic functions and immunological system. The circadian rhythm plays a vital role in health, and prolonged clock disruptions are associated with chronic diseases. The relationships between clock genes, aging, and immunosenescence are not well understood. Inflammation is an immune response triggered in living organisms in response to the danger associated with pathogens and injury. The term ‘inflammaging’ has been used to describe the chronic low-grade-inflammation that develops with advancing age and predicts susceptibility to age-related pathologies. Equilibrium between pro-and anti-inflammatory cytokines is needed for healthy aging and longevity. Sedentary and poor nutrition style life indices a disruption in circadian rhythm promoting an increase in pro-inflammatory factors or leads for chronic low-grade inflammation. Moreover, signals mediated by pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-6, might accentuate of the muscle loss during aging. Circadian clock is important to maintain the physiological functions, as maintenance of immune system. A strategy for imposes rhythmicity in the physiological systems may be adopted of exercise training routine. The lifelong regular practice of physical exercise decelerates the processes of aging, providing better quality and prolongation of life. Thus, in this review, we will focus on how aging affects circadian rhythms and its relationship to inflammatory processes (inflammaging), as well as the role of physical exercise as a regulator of the circadian rhythm, promoting aging with rhythmicity.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Post-Graduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP) School of Technology and Sciences-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Post-Graduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP) School of Technology and Sciences-
Descrição: dc.descriptionFAPESP: 2015/16777-0-
Descrição: dc.descriptionFAPESP: 2016/01409-8-
Descrição: dc.descriptionFAPESP: 2018/24187-6-
Descrição: dc.descriptionFAPESP: 2019/09854-9-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAging-
Palavras-chave: dc.subjectCircadian rhythms-
Palavras-chave: dc.subjectClock genes-
Palavras-chave: dc.subjectImmunosenescence-
Palavras-chave: dc.subjectInflammaging-
Título: dc.titleAging with rhythmicity. Is it possible? Physical exercise as a pacemaker-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.