A MATHEMATICAL MODEL for TREATMENT of PAPILLARY THYROID CANCER USING the ALLEE EFFECT

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorImagens Médicas de Brasília (IMEB)-
Autor(es): dc.contributorUniversidade de Brasília (UnB)-
Autor(es): dc.contributorInstitute Camille Jordan-
Autor(es): dc.creatorDa Silva, Jairo Gomes [UNESP]-
Autor(es): dc.creatorDe Morais, Rafael Martins-
Autor(es): dc.creatorDa Silva, Izabel Cristina Rodrigues-
Autor(es): dc.creatorAdimy, Mostafa-
Autor(es): dc.creatorDe Arruda Mancera, Paulo Fernando [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:43:42Z-
Data de disponibilização: dc.date.available2022-02-22T00:43:42Z-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2021-06-25-
Data de envio: dc.date.issued2020-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1142/S0218339020500138-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/205196-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/205196-
Descrição: dc.descriptionThe incidence of thyroid cancer is rising all over the world, and the papillary subtype (PTC) is the primary factor for this increase. The presence of thyroid tumors is commonly associated with increased levels of cytokines, such as interleukin 6 (IL-6). Considering PTC patients treated with thyroidectomy and radioactive iodine 131I (RAI), we propose an ordinary differential system using four variables: the RAI activity, the number of cancer cells and the serum concentrations of IL-6 and thyroglobulin (Tg). Our objective is to study the efficacy of different therapeutic doses of RAI in the treatment of thyroid cancer. The Allee effect is taken into account when modeling cancer cells growth under the influence of IL-6. From the results obtained, the main factors and conditions correlated with successful treatment, such as the RAI activity used and the tumor response are addressed. The detection of minimal doses of RAI that can cause tumor extinction is performed, though this has also meant longer periods for tumor cell elimination. The critical number of tumor cells due to the Allee effect is analyzed and linked to the immune system or biological factors that can slow the progression of the tumor but are insufficient after thyroid resection surgery.-
Descrição: dc.descriptionPrograma de Pós-Graduação em Biometria Universidade Estadual Paulista (UNESP) Instituto de Biociências Botucatu Sp-
Descrição: dc.descriptionImagens Médicas de Brasília (IMEB)-
Descrição: dc.descriptionUniversidade de Brasília (UnB) Faculdade de Ceilândia-
Descrição: dc.descriptionInria Univ Lyon Université de Lyon 1 Institute Camille Jordan, 43 Bd. du 11 novembre 1918-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Instituto de Biociências-
Descrição: dc.descriptionPrograma de Pós-Graduação em Biometria Universidade Estadual Paulista (UNESP) Instituto de Biociências Botucatu Sp-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Instituto de Biociências-
Formato: dc.format701-718-
Idioma: dc.languageen-
Relação: dc.relationJournal of Biological Systems-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectInterleukin 6-
Palavras-chave: dc.subjectOrdinary Differential Equations-
Palavras-chave: dc.subjectRadioiodine-
Palavras-chave: dc.subjectThyroid Tumor-
Título: dc.titleA MATHEMATICAL MODEL for TREATMENT of PAPILLARY THYROID CANCER USING the ALLEE EFFECT-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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