Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice

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Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorFederal University of Mato Grosso Do Sul-
Autor(es): dc.contributorYale University School of Public Health-
Autor(es): dc.contributorOswaldo Cruz Foundation-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorKassuya, Roberto Mikio-
Autor(es): dc.creatorRadai, Joyce Alencar Santos-
Autor(es): dc.creatorMacorini, Luis Fernando Benitez-
Autor(es): dc.creatorNunes, Viktor Krejci-
Autor(es): dc.creatorSalvador, Marcos José-
Autor(es): dc.creatorLeite, Patricia Regina Terço-
Autor(es): dc.creatorOliveira, Rodrigo Juliano-
Autor(es): dc.creatorCroda, Júlio-
Autor(es): dc.creatorArena, Arielle Cristina [UNESP]-
Autor(es): dc.creatorKassuya, Cândida Aparecida Leite-
Data de aceite: dc.date.accessioned2022-02-22T00:35:25Z-
Data de disponibilização: dc.date.available2022-02-22T00:35:25Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10787-020-00752-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/202097-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/202097-
Descrição: dc.descriptionInformation on the health benefits of ethanolic extracts obtained from Blutaparon portulacoides stem (EEBP) hasn´t been consistently described in the literature until the present moment. This study investigated the antimycobacterial, anti-inflammatory and toxicological effects of EEBP in models of inflammation/infection, as well as its chemical composition. Chemical analysis of EEBP by electrospray ionization–mass spectrometry/HPLC–MS/MS identified 3,5,3′-Trihydroxy-4′-methoxy-6,7-methylenedioxy-flavone, gomphrenol, ferulic, vanillic, and caffeic acids. The minimum inhibitory concentration of EEBP and isoniazid in the presence of Mycobacterium tuberculosis was 123.4 and 0.030 µg/ml, respectively. EEBP oral administration (p.o.) (300–1000 mg/kg) or dexamethasone subcutaneous injection (s.c.) (1 mg/kg) significantly inhibited leukocytes and proteins resulting from carrageenan-induced pleurisy in Swiss mice. In the BCG-induced pleurisy model, the oral treatments performed once a day for 7 days, with EEBP (30 and 100 mg/kg) and isoniazid (25 mg/kg), inhibited the increase in plasmatic IL-1β levels and in pleural exudate from C57BL-6 mice, and reduced M. tuberculosis growth in organs (colony forming units assays). EEBP (30–300 mg/kg, p.o.) and dexamethasone (1 mg/s.c.) significantly prevented carrageenan-induced oedema and mechanical hyperalgesia in Swiss mice. The treatments (once a day for 22 days) with EEBP (30 mg/kg, p.o.) and dexamethasone (1 mg/s.c.) substantially inhibited oedema and mechanical- and cold-hyperalgesia at 11, 16 and 22 days after the administration of Freund's Complete Adjuvant in C57bL6 mice. No evidence of physio-pathologic was observed in Wistar rats acutely treated with EEBP (2000 mg/kg, p.o.). This study confirms the anti-inflammatory and antibiotic properties of EEBP, opening possibilities for the development of safe new drugs with dual anti-inflammatory/antimycobacterial activities which could be favorable from a pharmacoeconomic perspective.-
Descrição: dc.descriptionFaculty of Health Sciences Federal University of Grande Dourados-
Descrição: dc.descriptionDepartment of Plant Biology PPG BTPB and PPG BCE Institute of Biology University of Campinas (UNICAMP), Campinas-
Descrição: dc.descriptionSchool of Medicine Federal University of Mato Grosso Do Sul-
Descrição: dc.descriptionDepartment of Epidemiology of Microbial Diseases Yale University School of Public Health-
Descrição: dc.descriptionOswaldo Cruz Foundation-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP) - Botucatu-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP) - Botucatu-
Idioma: dc.languageen-
Relação: dc.relationInflammopharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAmaranthaceae-
Palavras-chave: dc.subjectBlutaparon portulacoides-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectMycobacterium tuberculosis-
Título: dc.titleBlutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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