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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Federal University of Grande Dourados | - |
Autor(es): dc.contributor | Universidade Estadual de Campinas (UNICAMP) | - |
Autor(es): dc.contributor | Federal University of Mato Grosso Do Sul | - |
Autor(es): dc.contributor | Yale University School of Public Health | - |
Autor(es): dc.contributor | Oswaldo Cruz Foundation | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.creator | Kassuya, Roberto Mikio | - |
Autor(es): dc.creator | Radai, Joyce Alencar Santos | - |
Autor(es): dc.creator | Macorini, Luis Fernando Benitez | - |
Autor(es): dc.creator | Nunes, Viktor Krejci | - |
Autor(es): dc.creator | Salvador, Marcos José | - |
Autor(es): dc.creator | Leite, Patricia Regina Terço | - |
Autor(es): dc.creator | Oliveira, Rodrigo Juliano | - |
Autor(es): dc.creator | Croda, Júlio | - |
Autor(es): dc.creator | Arena, Arielle Cristina [UNESP] | - |
Autor(es): dc.creator | Kassuya, Cândida Aparecida Leite | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:35:25Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:35:25Z | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2020-12-11 | - |
Data de envio: dc.date.issued | 2019-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1007/s10787-020-00752-0 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/202097 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/202097 | - |
Descrição: dc.description | Information on the health benefits of ethanolic extracts obtained from Blutaparon portulacoides stem (EEBP) hasn´t been consistently described in the literature until the present moment. This study investigated the antimycobacterial, anti-inflammatory and toxicological effects of EEBP in models of inflammation/infection, as well as its chemical composition. Chemical analysis of EEBP by electrospray ionization–mass spectrometry/HPLC–MS/MS identified 3,5,3′-Trihydroxy-4′-methoxy-6,7-methylenedioxy-flavone, gomphrenol, ferulic, vanillic, and caffeic acids. The minimum inhibitory concentration of EEBP and isoniazid in the presence of Mycobacterium tuberculosis was 123.4 and 0.030 µg/ml, respectively. EEBP oral administration (p.o.) (300–1000 mg/kg) or dexamethasone subcutaneous injection (s.c.) (1 mg/kg) significantly inhibited leukocytes and proteins resulting from carrageenan-induced pleurisy in Swiss mice. In the BCG-induced pleurisy model, the oral treatments performed once a day for 7 days, with EEBP (30 and 100 mg/kg) and isoniazid (25 mg/kg), inhibited the increase in plasmatic IL-1β levels and in pleural exudate from C57BL-6 mice, and reduced M. tuberculosis growth in organs (colony forming units assays). EEBP (30–300 mg/kg, p.o.) and dexamethasone (1 mg/s.c.) significantly prevented carrageenan-induced oedema and mechanical hyperalgesia in Swiss mice. The treatments (once a day for 22 days) with EEBP (30 mg/kg, p.o.) and dexamethasone (1 mg/s.c.) substantially inhibited oedema and mechanical- and cold-hyperalgesia at 11, 16 and 22 days after the administration of Freund's Complete Adjuvant in C57bL6 mice. No evidence of physio-pathologic was observed in Wistar rats acutely treated with EEBP (2000 mg/kg, p.o.). This study confirms the anti-inflammatory and antibiotic properties of EEBP, opening possibilities for the development of safe new drugs with dual anti-inflammatory/antimycobacterial activities which could be favorable from a pharmacoeconomic perspective. | - |
Descrição: dc.description | Faculty of Health Sciences Federal University of Grande Dourados | - |
Descrição: dc.description | Department of Plant Biology PPG BTPB and PPG BCE Institute of Biology University of Campinas (UNICAMP), Campinas | - |
Descrição: dc.description | School of Medicine Federal University of Mato Grosso Do Sul | - |
Descrição: dc.description | Department of Epidemiology of Microbial Diseases Yale University School of Public Health | - |
Descrição: dc.description | Oswaldo Cruz Foundation | - |
Descrição: dc.description | Department of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP) - Botucatu | - |
Descrição: dc.description | Department of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP) - Botucatu | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Inflammopharmacology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Amaranthaceae | - |
Palavras-chave: dc.subject | Blutaparon portulacoides | - |
Palavras-chave: dc.subject | Inflammation | - |
Palavras-chave: dc.subject | Mycobacterium tuberculosis | - |
Título: dc.title | Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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