Chronic consumption of alcohol increases alveolar bone loss

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorde Almeida, Juliano Milanezi [UNESP]-
Autor(es): dc.creatorCabrera Pazmino, Victor Fabrizio [UNESP]-
Autor(es): dc.creatorNoronha Novaes, Vivian Cristina [UNESP]-
Autor(es): dc.creatorMogami Bomfim, Suely Regina [UNESP]-
Autor(es): dc.creatorHitomi Nagata, Maria José [UNESP]-
Autor(es): dc.creatorPinto Oliveira, Fred Lucas [UNESP]-
Autor(es): dc.creatorMatheus, Henrique Rinald [UNESP]-
Autor(es): dc.creatorErvolino, Edilson [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:35:16Z-
Data de disponibilização: dc.date.available2022-02-22T00:35:16Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0232731-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/202040-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/202040-
Descrição: dc.descriptionThis study evaluated the effects of the chronic consumption of different concentrations of alcohol on the experimental periodontitis (EP). 160 rats were divided into 4 groups: (EP-NT) rats with EP and no alcohol exposure; (EP-A14) rats with EP exposed to 14% alcohol; (EPA25) rats with EP exposed to 25% alcohol; (EP-A36) rats with EP exposed to 36% alcohol. The animals from the EP-A14, EP-A25 and EP-A36 groups were subjected to different concentrations of alcohol 30 days before EP induction. The histological characteristics, percentage of bone in the furcation (PBF) and bone metabolism in the furcation region were evaluated. The PBF and tartrate-resistant acid phosphatase (TRAP) data were subjected to statistical analysis. The EP-A14, EP-A25 and EP-A36 groups had lower PBFs compared with the EP-NT group. A more severe inflammatory process and a greater number of TRAP+ cells were also observed. In the EP-A14, EP-A25 and EP-A36 groups, the inflammatory process became more severe as the ingested alcoholic concentration increased. An increase in RANKL immunolabeling and a significantly higher number of TRAP+ cells were also observed. We conclude that chronic alcohol consumption increases the severity of experimental periodontitis in a dose-dependent manner by increasing the magnitude of local inflammatory responses and stimulating alveolar bone resorption.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Division of Periodontics São Paulo State University (Unesp) School of Dentistry-
Descrição: dc.descriptionDepartment of Clinic Surgery and Animal Reproduction São Paulo State University (Unesp) School of Veterinary Medicine-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (Unesp) School of Dentistry-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Division of Periodontics São Paulo State University (Unesp) School of Dentistry-
Descrição: dc.descriptionDepartment of Clinic Surgery and Animal Reproduction São Paulo State University (Unesp) School of Veterinary Medicine-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (Unesp) School of Dentistry-
Idioma: dc.languageen-
Relação: dc.relationPLoS ONE-
???dc.source???: dc.sourceScopus-
Título: dc.titleChronic consumption of alcohol increases alveolar bone loss-
Tipo de arquivo: dc.typelivro digital-
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