Conjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorCNRS-
Autor(es): dc.creatorde Santana, Willian Max O.S. [UNESP]-
Autor(es): dc.creatorCaetano, Bruno L. [UNESP]-
Autor(es): dc.creatorde Annunzio, Sarah Raquel [UNESP]-
Autor(es): dc.creatorPulcinelli, Sandra H. [UNESP]-
Autor(es): dc.creatorMénager, Christine-
Autor(es): dc.creatorFontana, Carla Raquel [UNESP]-
Autor(es): dc.creatorSantilli, Celso V. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:35:07Z-
Data de disponibilização: dc.date.available2022-02-22T00:35:07Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.colsurfb.2020.111297-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/202002-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/202002-
Descrição: dc.descriptionIn this work, we describe the synthesis and characterization of the SPIONP-CUR conjugate between curcumin (CUR) and superparamagnetic iron oxide nanoparticles (SPIONPs), in addition to its application in photodynamic therapy (PDT) using a protocol free of organic solvents as a dispersant. The SPIONP-CUR conjugate was characterized by X-ray diffraction, transmission electron microscopy, zeta potential measurements, Fourier transform infrared spectroscopy, thermogravimetry, magnetometry and magnetic hyperthermia assays. The SPIONP-CUR conjugation occurred by bonding between the keto-enol moiety of CUR and the iron atoms present on the surfaces of the SPIONPs. The conjugate showed heating power under an alternating magnetic field (AMF) and photodynamic action when irradiated with blue LED light. In experiments using PDT against Staphylococcus aureus in the planktonic phase, it was demonstrated that with application of blue light at 3.12 J cm−2, the conjugate (dispersed in water) caused a total reduction of the bacterial load. In the absence of light, the reduction was insignificant, even after 24 h of contact with the bacteria.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSoft Matter Sciences and Engineering ESPCI Paris PSL University Sorbonne Université CNRS-
Descrição: dc.descriptionPHysico-chimie des Electrolytes et Nanosystèmes InterfaciauX PHENIX Sorbonne Université CNRS-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionCNPq: #132543/2017-6-
Descrição: dc.descriptionCNPq: #147402/2019-0-
Descrição: dc.descriptionFAPESP: #2017/07822-7-
Descrição: dc.descriptionFAPESP: #2018/09088-1-
Descrição: dc.descriptionFAPESP: #2018/23015-7-
Descrição: dc.descriptionCNPq: #304900/2011-7-
Idioma: dc.languageen-
Relação: dc.relationColloids and Surfaces B: Biointerfaces-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntimicrobial-
Palavras-chave: dc.subjectCurcumin-
Palavras-chave: dc.subjectMagnetic nanoparticles-
Palavras-chave: dc.subjectPhotodynamic therapy-
Palavras-chave: dc.subjectStaphylococcus aureus-
Título: dc.titleConjugation of superparamagnetic iron oxide nanoparticles and curcumin photosensitizer to assist in photodynamic therapy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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