Toxicity of a methotrexate metronomic schedule in Wistar rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorCorreal, María Lucía [UNESP]-
Autor(es): dc.creatorCamplesi, Annelise Carla [UNESP]-
Autor(es): dc.creatorAnai, Letícia Abrahão [UNESP]-
Autor(es): dc.creatorBertolo, Paulo Henrique Leal [UNESP]-
Autor(es): dc.creatorVasconcelos, Rosemeri de Oliveira [UNESP]-
Autor(es): dc.creatorSantana, Áureo Evangelista [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:35:04Z-
Data de disponibilização: dc.date.available2022-02-22T00:35:04Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.rvsc.2020.07.015-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201984-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201984-
Descrição: dc.descriptionMetronomic chemotherapy is a relevant strategy that uses low doses of antineoplastic drugs for sustained periods to control tumor growth, an alternative frequently utilized in veterinary patients. This work aimed to evaluate the toxic effects of a metronomic oral dose of methotrexate (MTX) for 45 days in tumor-free Wistar rats when compared with control animals. Clinical alterations, body weight, food, and water intake were monitored daily, and bone marrow suppression, hematological, biochemical, and histopathological analyses were performed at three points (days 30, 45, and 60). MTX-treated animals did not demonstrate severe systemic involvement. At 30 days, compared with control animals, MTX-treated animals showed significant leukocytosis (11.9 ± 2.3 vs. 7.8 ± 0.2 106/μL; P <.05) and augmentation of immature myeloid populations from bone marrow (9.0 ± 0.8 vs. 6.5 ± 1.5%; P <.05), and at 60 days, treated animals showed significant neutrophilia (35.0 ± 11.0 vs. 23.00 ± 3.0%; P <.05), depletion of bone marrow lymphocytes (8.2 ± 0.7 vs. 11.5 ± 1.9%; P <.05), and immature myeloid populations (7.2 ± 0.7 vs. 8.3 ± 0.6%; P <.05). At a histopathological level, splenic hypoplasia and respiratory inflammatory lesions were significant when compared with control animals, presenting mild to moderate myelotoxicity, immune suppression, and associated clinical compromise that persisted beyond treatment withdrawal. This suggested that MTX metronomic toxicity should not be neglected owing to the observed residual side-effects and special care should be taken regarding myelosuppression.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp), Via de Acesso Prof. Paulo Donato Castellane s/n-
Descrição: dc.descriptionDepartment of Veterinary Pathology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp), Via de Acesso Prof. Paulo Donato Castellane s/n-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp), Via de Acesso Prof. Paulo Donato Castellane s/n-
Descrição: dc.descriptionDepartment of Veterinary Pathology School of Agricultural and Veterinarian Sciences São Paulo State University (Unesp), Via de Acesso Prof. Paulo Donato Castellane s/n-
Descrição: dc.descriptionCNPq: 304468/2013-4-
Formato: dc.format379-385-
Idioma: dc.languageen-
Relação: dc.relationResearch in Veterinary Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnimals-
Palavras-chave: dc.subjectAnti-folate-
Palavras-chave: dc.subjectCancer-
Palavras-chave: dc.subjectChemotherapy-
Palavras-chave: dc.subjectMetronomic-
Título: dc.titleToxicity of a methotrexate metronomic schedule in Wistar rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.