Panax ginseng metabolite (GIM-1) modulates the effects of monobutyl phthalate (MBP) on the GPR30/GPER1 canonical pathway in human Sertoli cells

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorde Freitas, André Teves A.G. [UNESP]-
Autor(es): dc.creatorPinho, Cristiane Figueiredo [UNESP]-
Autor(es): dc.creatorAquino, Ariana Musa [UNESP]-
Autor(es): dc.creatorDomeniconi, Raquel Fantin [UNESP]-
Autor(es): dc.creatorJustulin, Luis Antonio [UNESP]-
Autor(es): dc.creatorScarano, Wellerson Rodrigo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:35:02Z-
Data de disponibilização: dc.date.available2022-02-22T00:35:02Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2020.07.004-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201973-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201973-
Descrição: dc.descriptionThis study was performed to evaluate the effect of monobutyl phthalate (MBP) on GPR30-activated pathways in Sertoli cells. Additionally, we tested if GIM-1 (Panax ginseng metabolite) modulates MBP action. Human Sertoli cells (HSeC lineage) were exposed to MBP and/or GIM-1 for 30 min, 1, 12, and 48 h. Four experimental treatments were performed: control (DEMEM/F12 medium), MBP, GIM-1, and MBP + GIM-1. The results indicate that MBP activates GPR30, PKA, Src, EGFR, and the ERK1/2 proteins, while GIM-1 inhibits PKA, Src, ERK1/2, and the AKT pathway. MBP also enhances Cofilin expression, decreasing F-actin intensity on the cell surface in a short time. The combined exposure demonstrated a functional antagonism between compounds. Collectively, these data show that MBP activates GPR30 in Sertoli cells, and GIM-1 modulates this response, playing a protective role in Sertoli cells exposed to MBP.-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Department of Structural and Functional Biology-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences Department of Structural and Functional Biology-
Formato: dc.format209-215-
Idioma: dc.languageen-
Relação: dc.relationReproductive Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGIM-1-
Palavras-chave: dc.subjectGPR30/GPER1-
Palavras-chave: dc.subjectMBP-
Palavras-chave: dc.subjectPanax ginseng-
Palavras-chave: dc.subjectSertoli cells-
Título: dc.titlePanax ginseng metabolite (GIM-1) modulates the effects of monobutyl phthalate (MBP) on the GPR30/GPER1 canonical pathway in human Sertoli cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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