Expression of DNA repair genes in oral squamous cell carcinoma using reverse transcription-quantitative polymerase chain reaction

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Mogi das Cruzes-
Autor(es): dc.contributorBrazcubas Educação-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorSão Leopoldo Mandic Medical School-
Autor(es): dc.contributorHospital Municipal Dr. Mário Gatti-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorSão José dos Campos-
Autor(es): dc.creatorOliveira Alves, Mônica Ghislaine-
Autor(es): dc.creatorda Silva Miguel, Natália-
Autor(es): dc.creatorFerreira, Camila Cristina Panisello [UNESP]-
Autor(es): dc.creatorAlvarenga, Elis Ribeiro-
Autor(es): dc.creatorTonon, Bruna Manzanares-
Autor(es): dc.creatorde Barros, Patrícia Pimentel [UNESP]-
Autor(es): dc.creatorCarta, Celina Faig Lima [UNESP]-
Autor(es): dc.creatorPaschoal, Maria Beatriz Nogueira-
Autor(es): dc.creatorde Sales Chagas, José Francisco-
Autor(es): dc.creatorBandeira, Celso Muller [UNESP]-
Autor(es): dc.creatorNunes, Fábio Daumas-
Autor(es): dc.creatorAlmeida, Janete Dias [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:34:59Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:59Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.oooo.2020.06.003-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201953-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201953-
Descrição: dc.descriptionObjective: The aim of this study was to evaluate the expression of DNA repair genes in cases of oral squamous cell carcinoma (OSCC). Study Design: Expression of the MLH1, MSH2, MLH3, ATM, MRE11A, XRCC1, and PMS2 genes was evaluated by reverse transcription–quantitative polymerase chain reaction in the OSCC group (32 patients) and the control group (15 patients). The groups were compared by using the Mann-Whitney test, with Bonferroni correction. Associations between gene expression levels and clinical data were explored by using Pearson's and Spearman's correlation coefficients, with P value less than. 05 indicating a significant difference. Results: The MLH1, MSH2, MLH3, ATM, MRE11A, XRCC1, and PMS2 genes were downregulated in the OSCC group compared with the control group, with significant values for MLH1 (P < .0001); MSH2 (P = .038); MLH3 (P < .0001); ATM (P < .0001); MRE11A (P < .0001); XRCC1 (P = .0004); and PMS2 (P = .008). Analysis of the correlation between gene expression and clinical data only revealed a significant negative correlation between age and expression of the PMS2 gene. Conclusions: Expression of the DNA repair genes MLH1, MSH2, MLH3, ATM, MRE11 AMRE11A, XRCC1, and PMS2 was reduced in OSCC.-
Descrição: dc.descriptionSchool of Dentistry Universidade Mogi das Cruzes-
Descrição: dc.descriptionSchool of Dentistry Brazcubas Educação-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Head and Neck Surgery São Leopoldo Mandic Medical School-
Descrição: dc.descriptionDepartment of Head and Neck Surgery Hospital Municipal Dr. Mário Gatti-
Descrição: dc.descriptionDepartment of Oral Pathology School of Dentistry University of São Paulo-
Descrição: dc.descriptionSchool of Medicine Anhembi Morumbi University São José dos Campos-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology-
???dc.source???: dc.sourceScopus-
Título: dc.titleExpression of DNA repair genes in oral squamous cell carcinoma using reverse transcription-quantitative polymerase chain reaction-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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