Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.creatorde Oliveira, Miriane [UNESP]-
Autor(es): dc.creatorDe Sibio, Maria Teresa [UNESP]-
Autor(es): dc.creatorMathias, Lucas Solla [UNESP]-
Autor(es): dc.creatorRodrigues, Bruna Moretto [UNESP]-
Autor(es): dc.creatorSakalem, Marna Eliana-
Autor(es): dc.creatorNogueira, Célia Regina [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:34:59Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:59Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-09-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2020.110917-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201952-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201952-
Descrição: dc.descriptionObesity patients are more susceptible to develop COVID-19 severe outcome due to the role of angiotensin-converting enzyme 2 (ACE2) in the viral infection. ACE2 is regulated in the human cells by different genes associated with increased (TLR3, HAT1, HDAC2, KDM5B, SIRT1, RAB1A, FURIN and ADAM10) or decreased (TRIB3) virus replication. RNA-seq data revealed 14857 genes expressed in human subcutaneous adipocytes, including genes mentioned above. Irisin treatment increased by 3-fold the levels of TRIB3 transcript and decreased the levels of other genes. The decrease in FURIN and ADAM10 expression enriched diverse biological processes, including extracellular structure organization. Our results, in human subcutaneous adipocytes cell culture, indicate a positive effect of irisin on the expression of multiple genes related to viral infection by SARS-CoV-2; furthermore, translatable for other tissues and organs targeted by the novel coronavirus and present, thus, promising approaches for the treatment of COVID-19 infection as therapeutic strategy to decrease ACE2 regulatory genes.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Internal Clinic Botucatu Medicine School São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionDepartment of Anatomy Londrina State University (UEL)-
Descrição: dc.descriptionDepartment of Internal Clinic Botucatu Medicine School São Paulo State University (UNESP), Botucatu-
Descrição: dc.descriptionFAPESP: 2016/03242-3-
Descrição: dc.descriptionCNPq: 409438/2016-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectADAM10-
Palavras-chave: dc.subjectAdipose tissue-
Palavras-chave: dc.subjectFURIN-
Palavras-chave: dc.subjectIrisin-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectTRIB3-
Título: dc.titleIrisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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