Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats

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Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorFederal University of Maranhão (UFMA)-
Autor(es): dc.contributorH. Lee Moffitt Cancer Center and Research Institute-
Autor(es): dc.creatorRuberti, Olívia Moraes-
Autor(es): dc.creatorSousa, Andressa Silva-
Autor(es): dc.creatorViana, Laís Rosa-
Autor(es): dc.creatorPereira Gomes, Moisés Felipe-
Autor(es): dc.creatorMedeiros, Alessandra-
Autor(es): dc.creatorGomes Marcondes, Maria Cristina Cintra-
Autor(es): dc.creatorBorges, Luciano de Figueiredo-
Autor(es): dc.creatorCrestani, Carlos Cesar [UNESP]-
Autor(es): dc.creatorMostarda, Cristiano-
Autor(es): dc.creatorMoraes, Telma Fátima da Cunha-
Autor(es): dc.creatorCanevarolo, Rafael Renatino-
Autor(es): dc.creatorDelbin, Maria Andreia-
Autor(es): dc.creatorRodrigues, Bruno-
Data de aceite: dc.date.accessioned2022-02-22T00:34:57Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:57Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jcp.29919-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201940-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201940-
Descrição: dc.descriptionThis study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female Wistar rats were ovariectomized and divided into four groups: sedentary + sham (SS), sedentary + MI (SI), AT + sham surgery (TS), AT + MI (TI). AT was performed on a treadmill for 8 weeks before MI. Infarcted rats previously subjected to AT presented improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis identified and quantified 62 metabolites, 9 were considered significant by the Vip Score. SS, SI, and TS groups presented distinct metabolic profiles; however, TI could not be distinguished from the SS group. MI dramatically increased levels of dimethylamine, and AT prevented this response. Our findings suggest that AT may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI in ovariectomized rats.-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biology University of Campinas (UNICAMP)-
Descrição: dc.descriptionDepartment of Bioscience Federal University of São Paulo (UNIFESP)-
Descrição: dc.descriptionLaboratory of Pharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education Federal University of Maranhão (UFMA)-
Descrição: dc.descriptionSchool of Physical Education and Sport University of São Paulo-
Descrição: dc.descriptionDepartment of Cancer Physiology H. Lee Moffitt Cancer Center and Research Institute-
Descrição: dc.descriptionDepartment of Adapted Physical Activity School of Physical Education University of Campinas (UNICAMP)-
Descrição: dc.descriptionLaboratory of Pharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cellular Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectautonomic nervous system-
Palavras-chave: dc.subjectexercise-
Palavras-chave: dc.subjectmetabolomics-
Palavras-chave: dc.subjectmyocardial infarction-
Palavras-chave: dc.subjectovariectomy-
Título: dc.titleAerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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