Whole-genome sequencing provides new insights into genetic mechanisms of tropical adaptation in Nellore (Bos primigenius indicus)

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorFernandes Júnior, Gerardo Alves [UNESP]-
Autor(es): dc.creatorde Oliveira, Henrique Nunes [UNESP]-
Autor(es): dc.creatorCarvalheiro, Roberto [UNESP]-
Autor(es): dc.creatorCardoso, Diercles Francisco [UNESP]-
Autor(es): dc.creatorFonseca, Larissa Fernanda Simielli [UNESP]-
Autor(es): dc.creatorVentura, Ricardo Vieira-
Autor(es): dc.creatorde Albuquerque, Lucia Galvão [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:34:44Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:44Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-020-66272-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201868-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201868-
Descrição: dc.descriptionMost of the knowledge about genetic variants at the sequence level in cattle is for Bos primigenius taurus populations. Here, we presented a complete genomic characterization of 52 Nellore (Bos primigenius indicus) bulls, revealing specific zebu DNA variants with putative impact in tropical adaptation and productive traits. Single nucleotide polymorphisms (SNPs) and insertion/deletion (INDELs) mutations were identified using the newest bovine reference genome ARS_UCD1.2, and variant functional consequences were predicted using the Ensembl VEP software. A total of 35,753,707 SNPs and 4,492,636 INDELs were detected and annotated to their functional effects. We identified 400 genes that comprised both, a SNP and an INDEL, of high functional impact on proteins (i.e. variants that cause protein truncation, loss of function or triggering nonsense-mediated decay). Among these, we highlight the following genes: BoLA, associated with cattle immune response to infections and reproduction aspects; HSPA8, DNAJC27, and DNAJC28, involved with thermoregulatory protective mechanisms in mammals; and many olfactory signaling pathway related genes that are important genetic factors in the evolution of mammalian species. All these functional aspects are directly related to cattle adaptability to tropical environments.-
Descrição: dc.descriptionSchool of Agricultural and Veterinarian Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science University of São Paulo (USP)-
Descrição: dc.descriptionSchool of Agricultural and Veterinarian Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleWhole-genome sequencing provides new insights into genetic mechanisms of tropical adaptation in Nellore (Bos primigenius indicus)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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