Anti-hypertensive effect of hydrogen peroxide acting centrally

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorPontifical Catholic University of Goias-
Autor(es): dc.creatorLauar, Mariana R. [UNESP]-
Autor(es): dc.creatorBlanch, Graziela T.-
Autor(es): dc.creatorColombari, Débora S. A. [UNESP]-
Autor(es): dc.creatorColombari, Eduardo [UNESP]-
Autor(es): dc.creatorDe Paula, Patrícia M. [UNESP]-
Autor(es): dc.creatorDe Luca, Laurival A. [UNESP]-
Autor(es): dc.creatorMenani, José V. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:34:34Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:34Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41440-020-0474-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201813-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201813-
Descrição: dc.descriptionIntracerebroventricular (icv) injection of hydrogen peroxide (H2O2) or the increase of endogenous H2O2 centrally produced by catalase inhibition with 3-amino-1,2,4-triazole (ATZ) injected icv reduces the pressor responses to central angiotensin II (ANG II) in normotensive rats. In the present study, we investigated the changes in the arterial pressure and in the pressor responses to ANG II icv in spontaneously hypertensive rats (SHRs) and 2-kidney, 1-clip (2K1C) hypertensive rats treated with H2O2 injected icv or ATZ injected icv or intravenously (iv). Adult male SHRs or Holtzman rats (n = 5–10/group) with stainless steel cannulas implanted in the lateral ventricle were used. In freely moving rats, H2O2 (5 μmol/1 μl) or ATZ (5 nmol/1 μl) icv reduced the pressor responses to ANG II (50 ng/1 µl) icv in SHRs (11 ± 3 and 17 ± 4 mmHg, respectively, vs. 35 ± 6 mmHg) and 2K1C hypertensive rats (3 ± 1 and 16 ± 3 mmHg, respectively, vs. 26 ± 2 mmHg). ATZ (3.6 mmol/kg of body weight) iv alone or combined with H2O2 icv also reduced icv ANG II-induced pressor response in SHRs and 2K1C hypertensive rats. Baseline arterial pressure was also reduced (−10 to −15 mmHg) in 2K1C hypertensive rats treated with H2O2 icv and ATZ iv alone or combined and in SHRs treated with H2O2 icv alone or combined with ATZ iv. The results suggest that exogenous or endogenous H2O2 acting centrally produces anti-hypertensive effects impairing central pressor mechanisms activated by ANG II in SHRs or 2K1C hypertensive rats.-
Descrição: dc.descriptionDepartment of Physiology and Pathology Dentistry School São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Medicine Pharmacy and Biomedicine Pontifical Catholic University of Goias-
Descrição: dc.descriptionDepartment of Physiology and Pathology Dentistry School São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationHypertension Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject2K1C hypertension-
Palavras-chave: dc.subjectAngiotensin-
Palavras-chave: dc.subjectCatalase inhibition-
Palavras-chave: dc.subjectH2O2-
Palavras-chave: dc.subjectReactive oxygen species-
Palavras-chave: dc.subjectSHR-
Título: dc.titleAnti-hypertensive effect of hydrogen peroxide acting centrally-
Tipo de arquivo: dc.typelivro digital-
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