Chemical Characterization and Wound Healing Property of Jacaranda decurrens Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms

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Autor(es): dc.contributorFederal University of Maranhaõ-
Autor(es): dc.contributorUniversity of Saõ Paulo-
Autor(es): dc.contributorRio Branco-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSerra, Mariana B.-
Autor(es): dc.creatorBarroso, Wermerson A.-
Autor(es): dc.creatorRocha, Claúdia-
Autor(es): dc.creatorFurtado, Pablo G.R.-
Autor(es): dc.creatorBorges, Antônio C.R.-
Autor(es): dc.creatorSilva, Selma N.-
Autor(es): dc.creatorTangerina, Marcelo M. P. [UNESP]-
Autor(es): dc.creatorNascimento, Jessyane R. Do-
Autor(es): dc.creatorVilegas, Wagner [UNESP]-
Autor(es): dc.creatorAlves, Ademilton C.-
Autor(es): dc.creatorBarbeiro, Denise F.-
Autor(es): dc.creatorDe Souza, Heraldo P.-
Autor(es): dc.creatorAbreu, Iracelle C.-
Autor(es): dc.creatorBorges, Marilene O.R.-
Data de aceite: dc.date.accessioned2022-02-22T00:34:24Z-
Data de disponibilização: dc.date.available2022-02-22T00:34:24Z-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2020-12-11-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2020/4749712-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/201743-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/201743-
Descrição: dc.descriptionBackground. Jacaranda decurrens Cham., known as carobinha, is prevalent in the Cerrado biome and presents popular use in treatment of dermatological diseases. The present study aimed to investigate the healing action of topical formulation of Jacaranda decurrens Cham. (FtEHJ) in mice cutaneous lesions. Methods. Phytochemical analysis of J. decurrens hydroalcoholic extract was carried out by using HPLC-PDA-ESI-MS and FIA-ESI-IT-MSn. Swiss mice were treated topically with formulation base (FtB) or Fibrinase® or ointment FtEHJ (15 mg/g; 50 mg/Kg). At the end of treatment periods, the inflammatory cytokines (TNF-, IL-1β, and IL-6) in the lesions were measured by using ELISA and gene expression of TGF-β, Collagen I, and Collagen III was demonstrated by RTqPCR method and histological evaluation. Results. Ten compounds were identified in the extract, distributed among the classes of flavonoids and triterpenes. Treatment with FtEHJ increased the wound contraction in 24 hours, such as reduction of TNF-, IL-1β, and IL-6 (pg/mL) cytokines in the lesion. The TGF-β and collagen gene expression was increased and the wound closure accelerated to nine days, with discrete inflammation, collagenization, and accented reepithelialization. Conclusions. The results obtained suggest chemical compounds present in the FtEHJ accelerates wound healing by being a gene expression modulator, and protein content of different molecules are involved in tissue repair.-
Descrição: dc.descriptionPhysiological Sciences Department Federal University of Maranhaõ-
Descrição: dc.descriptionClinical Medicine Department University of Saõ Paulo-
Descrição: dc.descriptionDepartment of Chemistry Federal University of Maranhaõ-
Descrição: dc.descriptionDNA Medical Diagnóstics Rio Branco-
Descrição: dc.descriptionInstitute of Biosciences Paulista State University (UNESP)-
Descrição: dc.descriptionPharmacy Department Federal University of Maranhaõ-
Descrição: dc.descriptionInstitute of Biosciences Paulista State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationEvidence-based Complementary and Alternative Medicine-
???dc.source???: dc.sourceScopus-
Título: dc.titleChemical Characterization and Wound Healing Property of Jacaranda decurrens Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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